Detailed view for Bm1_57375

Basic information

TDR Targets ID: 236842
Brugia malayi, 60S ribosomal protein L9
Source Database / ID:  GenBank

pI: 10.6169 | Length (AA): 188 | MW (Da): 21570 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00347   Ribosomal protein L6

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0019843   rRNA binding  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 86 2cql (A) 1 88 53.00 0 1 1.08195 -0.39
10 182 1vq8 (E) 5 171 34.00 0 1 1.36141 -0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126993)

Species Accession Gene Product
Arabidopsis thaliana AT1G33120   60S ribosomal protein L9-1
Arabidopsis thaliana AT1G33140   60S ribosomal protein L9-1
Arabidopsis thaliana AT4G10450   60S ribosomal protein L9-2
Babesia bovis BBOV_IV006070   ribosomal protein L9, putative
Brugia malayi Bm1_57375   60S ribosomal protein L9
Candida albicans CaO19.236   likely cytosolic ribosomal protein similar to S. cerevisiae RPL9A (YGL147C) and RPL9B (YNL067W) large subunit protein L9
Candida albicans CaO19.7866   likely cytosolic ribosomal protein similar to S. cerevisiae RPL9A (YGL147C) and RPL9B (YNL067W) large subunit protein L9
Caenorhabditis elegans CELE_R13A5.8   Protein RPL-9
Cryptosporidium hominis Chro.80052   ribosomal protein
Cryptosporidium parvum cgd8_400   60S ribosomal protein L9
Dictyostelium discoideum DDB_G0278959   60S ribosomal protein L9
Drosophila melanogaster Dmel_CG6141   Ribosomal protein L9
Echinococcus granulosus EgrG_001076300   ribosomal protein L9
Entamoeba histolytica EHI_193080   60S ribosomal protein L9, putative
Entamoeba histolytica EHI_126140   60S ribosomal protein L9, putative
Echinococcus multilocularis EmuJ_001076300   ribosomal protein L9
Giardia lamblia GL50803_17056   Ribosomal protein L9
Homo sapiens ENSG00000163682   ribosomal protein L9
Leishmania braziliensis LbrM.21.1280   60S ribosomal protein L9, putative
Leishmania braziliensis LbrM.30.3380   60S ribosomal protein L9, putative
Leishmania donovani LdBPK_211290.1   60S ribosomal protein L9, putative
Leishmania infantum LinJ.30.3390   60S ribosomal protein L9, putative
Leishmania infantum LinJ.21.1290   60S ribosomal protein L9, putative
Leishmania major LmjF.30.3340   60S ribosomal protein L9, putative
Leishmania major LmjF.21.1050   60S ribosomal protein L9, putative
Leishmania mexicana LmxM.29.3340   60S ribosomal protein L9, putative
Leishmania mexicana LmxM.21.1050   60S ribosomal protein L9, putative
Loa Loa (eye worm) LOAG_09683   hypothetical protein
Loa Loa (eye worm) LOAG_05986   60S ribosomal protein L9
Mus musculus ENSMUSG00000047215   ribosomal protein L9
Mus musculus 102641773   60S ribosomal protein L9-like
Mus musculus 101056029   60S ribosomal protein L9-like
Neospora caninum NCLIV_015160   hypothetical protein
Oryza sativa 4347422   Os09g0485900
Oryza sativa 4327999   Os02g0103700
Plasmodium berghei PBANKA_1338300   60S ribosomal protein L6, putative
Plasmodium falciparum PF3D7_1323100   60S ribosomal protein L6, putative
Plasmodium knowlesi PKNH_1205700   60S ribosomal protein L6, putative
Plasmodium vivax PVX_116715   60S ribosomal protein L9, putative
Plasmodium yoelii PY01587   ribosomal protein L6, putative
Saccharomyces cerevisiae YGL147C   ribosomal 60S subunit protein L9A
Saccharomyces cerevisiae YNL067W   ribosomal 60S subunit protein L9B
Schistosoma japonicum Sjp_0075950   ko:K02940 large subunit ribosomal protein L9e, putative
Schistosoma mansoni Smp_018990   60S ribosomal protein L9
Schmidtea mediterranea mk4.007424.01   60S ribosomal protein L9
Schmidtea mediterranea mk4.030660.00   60S ribosomal protein L9
Trypanosoma brucei gambiense Tbg972.6.4510   60S ribosomal protein L9, putative
Trypanosoma brucei gambiense Tbg972.10.1300   60S ribosomal protein L9, putative
Trypanosoma brucei Tb927.10.1100   60S ribosomal protein L9, putative
Trypanosoma congolense TcIL3000_10_900   60S ribosomal protein L9, putative
Trypanosoma congolense TcIL3000_6_4130   60S ribosomal protein L9, putative
Trypanosoma cruzi TcCLB.509695.170   60S ribosomal protein L9, putative
Trypanosoma cruzi TcCLB.506835.30   60S ribosomal protein L9, putative
Trypanosoma cruzi TcCLB.511729.40   60S ribosomal protein L9, putative
Trypanosoma cruzi TcCLB.504181.10   60S ribosomal protein L9, putative
Toxoplasma gondii TGME49_284560   ribosomal protein RPL9
Theileria parva TP01_0413   60S ribosomal protein L6, putative
Trichomonas vaginalis TVAG_255140   60S ribosomal protein L9, putative
Trichomonas vaginalis TVAG_054500   50S ribosomal protein L6p, putative
Trichomonas vaginalis TVAG_318710   50S ribosomal protein L6p, putative
Trichomonas vaginalis TVAG_198960   60S ribosomal protein L9, putative
Trichomonas vaginalis TVAG_297470   60S ribosomal protein L9, putative

Essentiality

Bm1_57375 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1100 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1100 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1100 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1100 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R13A5.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_R13A5.8 Caenorhabditis elegans larval arrest wormbase
CELE_R13A5.8 Caenorhabditis elegans slow growth wormbase
CELE_R13A5.8 Caenorhabditis elegans sterile wormbase
PBANKA_1338300 Plasmodium berghei Essential plasmo
TGME49_284560 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57375 (Brugia malayi), 60S ribosomal protein L9
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