Detailed view for Bm1_11930

Basic information

TDR Targets ID: 237046
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 7.3135 | Length (AA): 1038 | MW (Da): 117282 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01930   Domain of unknown function DUF83
PF08696   DNA replication factor Dna2
PF13086   AAA domain
PF13087   AAA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0043142   single-stranded DNA-dependent ATPase activity  
GO:0033567   DNA replication, Okazaki fragment processing  
GO:0017108   5'-flap endonuclease activity  
GO:0005524   ATP binding  
GO:0004003   ATP-dependent DNA helicase activity  
GO:0003677   DNA binding  
GO:0006260   DNA replication  

Metabolic Pathways

DNA replication (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 1031 5ean (A) 32 1038 27.00 0 1 1.18663 0.2
110 1031 5ean (A) 87 1038 33.00 0 1 1.20565 -0.07
613 690 2is1 (B) 3 81 22.00 0 0.94 0.294645 -0.23
620 1025 4b3f (X) 192 627 31.00 0 1 0.591537 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129631)

Species Accession Gene Product
Arabidopsis thaliana AT1G08840   embryo defective protein 2411
Brugia malayi Bm1_11930   hypothetical protein
Candida albicans CaO19.1192   DNA helicase, ssDNA-dependent ATPase, and endonuclease
Candida albicans CaO19.8783   DNA helicase, ssDNA-dependent ATPase, and endonuclease
Caenorhabditis elegans CELE_F43G6.1   Protein DNA-2, isoform B
Dictyostelium discoideum DDB_G0274777   DEAD/DEAH box helicase domain-containing protein
Drosophila melanogaster Dmel_CG2990   CG2990 gene product from transcript CG2990-RB
Echinococcus granulosus EgrG_000744400   dna2 helicase
Echinococcus multilocularis EmuJ_000744400   dna2 helicase
Homo sapiens ENSG00000138346   DNA replication helicase/nuclease 2
Loa Loa (eye worm) LOAG_06948   hypothetical protein
Mus musculus ENSMUSG00000036875   DNA replication helicase 2 homolog (yeast)
Oryza sativa 4336807   Os04g0588200
Saccharomyces cerevisiae YHR164C   Dna2p
Schistosoma japonicum Sjp_0039060   ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative
Schistosoma japonicum Sjp_0311290   expressed protein
Schistosoma japonicum Sjp_0065280   Transmembrane protein 34, putative
Schistosoma mansoni Smp_126930   DNA replication helicase
Schmidtea mediterranea mk4.000036.10   DNA replication ATP-dependent helicase/nuclease DNA2
Schmidtea mediterranea mk4.000036.07  
Schmidtea mediterranea mk4.014048.01   DNA replication ATP-dependent helicase/nuclease DNA2
Schmidtea mediterranea mk4.000036.08   DNA replication ATP-dependent helicase/nuclease DNA2
Schmidtea mediterranea mk4.009077.00   DNA replication ATP-dependent helicase/nuclease DNA2
Trichomonas vaginalis TVAG_461840   DNA replication helicase DNA2, putative
Trichomonas vaginalis TVAG_461790   DNA helicase, putative

Essentiality

Bm1_11930 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F43G6.1 Caenorhabditis elegans embryonic lethal wormbase
YHR164C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

6 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_11930 (Brugia malayi), hypothetical protein
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