Detailed view for Bm1_23965

Basic information

TDR Targets ID: 237077
Brugia malayi, tricarboxylate transport protein, mitochondrial precursor
Source Database / ID:  GenBank

pI: 10.0001 | Length (AA): 302 | MW (Da): 33562 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0005215   transporter activity  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 292 1okc (A) 8 293 29.00 0 0.29 1.0774 0.47
59 136 1ile (A) 544 625 32.00 0.59 0.22 0.412078 1.33
160 248 3pev (B) 412 503 10.00 0 0 0.333302 -0.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129733)

Species Accession Gene Product
Brugia malayi Bm1_23965   tricarboxylate transport protein, mitochondrial precursor
Candida albicans CaO19.5870   likely mitochondrial citrate transporter similar to S. cerevisiae CTP1 (YBR291C)
Candida albicans CaO19.13291   likely mitochondrial citrate transporter similar to S. cerevisiae CTP1 (YBR291C)
Caenorhabditis elegans CELE_K11H3.3   Protein K11H3.3
Drosophila melanogaster Dmel_CG6782   scheggia
Echinococcus granulosus EgrG_000902600   tricarboxylate transport protein
Echinococcus multilocularis EmuJ_000902600   tricarboxylate transport protein
Homo sapiens ENSG00000100075   solute carrier family 25 (mitochondrial carrier
Loa Loa (eye worm) LOAG_03395   hypothetical protein
Mus musculus ENSMUSG00000003528   solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
Onchocerca volvulus OVOC7693   Tricarboxylate transport protein, mitochondrial homolog
Saccharomyces cerevisiae YBR291C   Ctp1p
Schistosoma mansoni Smp_149320   tricarboxylate transport protein
Trypanosoma cruzi TcCLB.509561.30   citrate transporter, putative
Trypanosoma cruzi TcCLB.503897.170   citrate transporter, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_23965 (Brugia malayi), tricarboxylate transport protein, mitochondrial precursor
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