Detailed view for Bm1_11605

Basic information

TDR Targets ID: 237099
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 7.4782 | Length (AA): 1726 | MW (Da): 193341 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00498   FHA domain
PF00595   PDZ domain (Also known as DHR or GLGF)
PF00788   Ras association (RalGDS/AF-6) domain
PF01843   DIL domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005911   intercellular junction  
GO:0005515   protein binding  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 134 3ddc (B) 204 357 22.00 0 0.97 0.269504 -0.96
44 132 5kho (A) 146 255 21.00 0 0.39 0.216964 -1
219 307 1wxa (A) 7 88 39.00 0.000028 0.77 0.356364 0.35
221 327 2m4n (A) 4 105 37.00 0 1 0.438393 -0.7
403 471 3fm8 (A) 473 541 33.00 0.18 1 0.509777 -0.77
624 975 4lx0 (B) 1466 1840 21.00 0 1 0.29734 -0.17
1054 1149 2exg (A) 7 101 53.00 0 1 0.60902 -0.08
1058 1144 2qg1 (A) 1722 1805 36.00 0 1 0.465806 -0.89
1090 1142 1r6j (A) 218 269 31.00 0.98 1 0.422507 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132661)

Species Accession Gene Product
Brugia malayi Bm1_11605   hypothetical protein
Caenorhabditis elegans CELE_W03F11.6   Protein AFD-1, isoform D
Drosophila melanogaster Dmel_CG42312   canoe
Echinococcus granulosus EgrG_001145800   myeloid:lymphoid or mixed lineage leukemia
Echinococcus multilocularis EmuJ_001145800   myeloid:lymphoid or mixed lineage leukemia
Homo sapiens ENSG00000130396   myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Loa Loa (eye worm) LOAG_04372   hypothetical protein
Loa Loa (eye worm) LOAG_07700   hypothetical protein
Loa Loa (eye worm) LOAG_11643   hypothetical protein
Mus musculus ENSMUSG00000068036   myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Schistosoma mansoni Smp_169130   afadin (af-6 protein)
Schmidtea mediterranea mk4.000819.01  
Schmidtea mediterranea mk4.000819.00  
Schmidtea mediterranea mk4.004677.00   Afadin
Schmidtea mediterranea mk4.014509.00   Afadin
Schmidtea mediterranea mk4.014509.01  
Schmidtea mediterranea mk4.000791.09   Afadin

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_11605 (Brugia malayi), hypothetical protein
Title for this comment
Comment