Detailed view for Bm1_18310

Basic information

TDR Targets ID: 237121
Brugia malayi, eIF4-gamma/eIF5/eIF2-epsilon family protein
Source Database / ID:  GenBank

pI: 4.5576 | Length (AA): 640 | MW (Da): 73277 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00132   Bacterial transferase hexapeptide (six repeats)
PF02020   eIF4-gamma/eIF5/eIF2-epsilon

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0016740   transferase activity  
GO:0005515   protein binding  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 434 5b04 (I) 15 440 17.00 0.45 1 0.90325 -0.01
15 81 2ux8 (A) 4 70 15.00 0.93 0.09 0.202688 0.47
323 390 4ihf (A) 108 172 40.00 0.015 0.99 0.58635 -0.98
324 416 3r1w (A) 37 145 28.00 0.12 1 0.565413 -2.17
477 636 3jui (A) 540 715 28.00 0 1 0.681 -1.45
477 636 3jui (A) 544 715 31.00 0 1 0.6985 -1.9
588 638 2iu1 (A) 329 389 39.00 0.15 0.96 0.273787 0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128210)

Species Accession Gene Product
Arabidopsis thaliana AT2G34970   trimeric LpxA-like enzyme
Arabidopsis thaliana AT3G02270   trimeric LpxA-like enzyme
Arabidopsis thaliana AT4G18300   Trimeric LpxA-like enzyme
Babesia bovis BBOV_IV001400   translation initiation factor eIF epsilon subunit, putative
Brugia malayi Bm1_18310   eIF4-gamma/eIF5/eIF2-epsilon family protein
Candida albicans CaO19.407   similar to S. cerevisiae GCD6 (YDR211W) epsilon subunit of eIF-2B, the guanine nucleotide exchange factor for translation initia
Candida albicans CaO19.8037   similar to S. cerevisiae GCD6 (YDR211W) epsilon subunit of eIF-2B, the guanine nucleotide exchange factor for translation initia
Caenorhabditis elegans CELE_D2085.3   Protein D2085.3
Cryptosporidium hominis Chro.60395   translation initiation factor eif-2b epsilon subunit
Cryptosporidium parvum cgd6_3420   translation initiation factor EIF-2B epsilon subunit
Dictyostelium discoideum DDB_G0283163   bacterial transferase hexapeptide repeat-containing protein
Drosophila melanogaster Dmel_CG3806   CG3806 gene product from transcript CG3806-RB
Echinococcus granulosus EgrG_001094700   translation initiation factor eIF 2B subunit
Entamoeba histolytica EHI_131020   translation initiation factor eIF-2B epsilon subunit, putative
Echinococcus multilocularis EmuJ_001094700   translation initiation factor eIF 2B subunit
Giardia lamblia GL50803_39587   Translation initiation factor
Homo sapiens ENSG00000145191   eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Loa Loa (eye worm) LOAG_09004   hypothetical protein
Loa Loa (eye worm) LOAG_09005   hypothetical protein
Mus musculus ENSMUSG00000003235   eukaryotic translation initiation factor 2B, subunit 5 epsilon
Neospora caninum NCLIV_034670   hypothetical protein
Neospora caninum NCLIV_033550   hypothetical protein
Oryza sativa 4331104   Os02g0812400
Plasmodium berghei PBANKA_1429700   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1213900   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_123385   hypothetical protein, conserved
Plasmodium yoelii PY02019   hypothetical protein
Saccharomyces cerevisiae YDR211W   Gcd6p
Schistosoma japonicum Sjp_0002720   ko:K03240 translation initiation factor eIF-2B epsilon subunit, putative
Schistosoma japonicum Sjp_0002730   ko:K03240 translation initiation factor eIF-2B epsilon subunit, putative
Schistosoma mansoni Smp_019380   eukariotic translation initiation factor 2b epsilon subunit
Schmidtea mediterranea mk4.002778.01   Translation initiation factor eIF-2B subunit epsilon
Toxoplasma gondii TGME49_274190   eukaryotic initiation factor 2B epsilon subunit, putative
Toxoplasma gondii TGME49_272640   eukaryotic initiation factor-2B, epsilon subunit, putative
Theileria parva TP01_0167   translation initiation factor eIF-2B epsilon subunit, putative
Trichomonas vaginalis TVAG_498830   mannose-1-phosphate guanyltransferase, putative

Essentiality

Bm1_18310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_D2085.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_D2085.3 Caenorhabditis elegans larval arrest wormbase
CELE_D2085.3 Caenorhabditis elegans slow growth wormbase
YDR211W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1429700 Plasmodium berghei Essential plasmo
TGME49_274190 Toxoplasma gondii Probably non-essential sidik
TGME49_272640 Toxoplasma gondii Probably non-essential sidik
TGME49_274190 Toxoplasma gondii Probably essential sidik
TGME49_272640 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_18310 (Brugia malayi), eIF4-gamma/eIF5/eIF2-epsilon family protein
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