Detailed view for Bm1_00390

Basic information

TDR Targets ID: 237151
Brugia malayi, CG1676-PA
Source Database / ID:  GenBank

pI: 7.6383 | Length (AA): 603 | MW (Da): 71778 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09732   Cactus-binding C-terminus of cactin protein
PF10312   Conserved mid region of cactin

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 70 2jee (A) 11 80 9.00 0.19 0 0.408186 -2.59
6 454 4h5y (A) 150 550 18.00 0 0.86 0.67781 0.8
7 178 4tql (A) 82 231 30.00 0.12 0.66 0.48724 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129462)

Species Accession Gene Product
Arabidopsis thaliana AT1G03910   hypothetical protein
Babesia bovis BBOV_IV002000   conserved hypothetical protein
Brugia malayi Bm1_00390   CG1676-PA
Caenorhabditis elegans CELE_W03H9.4   Protein CACN-1, isoform A
Caenorhabditis elegans CELE_W03H9.4a   Protein CACN-1, isoform B
Cryptosporidium hominis Chro.50213   hypothetical protein
Cryptosporidium parvum cgd5_1690   cactin-like protein
Dictyostelium discoideum DDB_G0279317   hypothetical protein
Drosophila melanogaster Dmel_CG1676   CG1676 gene product from transcript CG1676-RB
Echinococcus granulosus EgrG_000774000   Cactin protein cactus binding domain C terminal
Echinococcus multilocularis EmuJ_000774000   Cactin protein, cactus binding domain, C terminal
Homo sapiens ENSG00000105298   cactin, spliceosome C complex subunit
Loa Loa (eye worm) LOAG_03867   C19orf29 protein
Mus musculus ENSMUSG00000034889   cactin, spliceosome C complex subunit
Neospora caninum NCLIV_018940   hypothetical protein, conserved
Oryza sativa 9268667   Os03g0800100
Plasmodium berghei PBANKA_1226400   cactin homolog, putative
Plasmodium falciparum PF3D7_0804000   cactin homolog, putative
Plasmodium knowlesi PKNH_0115000   cactin homolog, putative
Plasmodium vivax PVX_093550   cactin homolog, putative
Plasmodium yoelii PY00804   similar to cactin-related
Plasmodium yoelii PY00805   cactin gene product
Schistosoma japonicum Sjp_0020590   similar to Uncharacterized protein C19orf29, putative
Schistosoma mansoni Smp_038640   cactin-related
Schmidtea mediterranea mk4.000369.09  
Schmidtea mediterranea mk4.000564.07  
Toxoplasma gondii TGME49_244380   cactin
Theileria parva TP03_0454   hypothetical protein
Theileria parva TP03_0453   hypothetical protein
Trichomonas vaginalis TVAG_118990   conserved hypothetical protein

Essentiality

Bm1_00390 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W03H9.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_W03H9.4 Caenorhabditis elegans larval arrest wormbase
CELE_W03H9.4 Caenorhabditis elegans slow growth wormbase
CELE_W03H9.4 Caenorhabditis elegans sterile wormbase
TGME49_244380 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00390 (Brugia malayi), CG1676-PA
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