Detailed view for Bm1_40175

Basic information

TDR Targets ID: 237198
Brugia malayi, Major Facilitator Superfamily protein
Source Database / ID:  GenBank

pI: 8.3457 | Length (AA): 472 | MW (Da): 52222 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
44 451 4zp0 (A) 15 399 16.00 0 0.26 0.971307 -0.01
425 462 3eo9 (H) 84 121 42.00 0.25 0.05 0.131108 3.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126977)

Species Accession Gene Product
Arabidopsis thaliana AT2G29650   1
Arabidopsis thaliana AT4G00370   inorganic phosphate transporter PHT4
Arabidopsis thaliana AT2G38060   2
Brugia malayi Bm1_14785   Major Facilitator Superfamily protein
Brugia malayi Bm1_14775   Major Facilitator Superfamily protein
Brugia malayi Bm1_40175   Major Facilitator Superfamily protein
Brugia malayi Bm1_44400   Major Facilitator Superfamily protein
Caenorhabditis elegans CELE_ZK512.6   Protein EAT-4
Caenorhabditis elegans CELE_K10G9.1   Protein VGLU-2
Caenorhabditis elegans CELE_T07A5.3   Protein VGLU-3
Caenorhabditis elegans CELE_C38C10.2   Protein C38C10.2
Caenorhabditis elegans CELE_ZK54.1   Protein ZK54.1, isoform A
Cryptosporidium hominis Chro.80449   hypothetical protein
Cryptosporidium parvum cgd8_3910   Na-dependent inorganic phosphate cotransporter with 12 transmembrane domains
Dictyostelium discoideum DDB_G0280761   hypothetical protein
Dictyostelium discoideum DDB_G0279943   hypothetical protein
Drosophila melanogaster Dmel_CG4288   CG4288 gene product from transcript CG4288-RB
Drosophila melanogaster Dmel_CG4330   Major Facilitator Superfamily Transporter 10
Drosophila melanogaster Dmel_CG15095   lethal (2) 08717
Drosophila melanogaster Dmel_CG9887   Vesicular glutamate transporter
Escherichia coli b3691   D-galactonate transporter
Escherichia coli b2789   putative D-glucarate transporter
Echinococcus granulosus EgrG_000249800   vesicular glutamate transporter
Echinococcus multilocularis EmuJ_000249800   vesicular glutamate transporter
Homo sapiens ENSG00000119899   solute carrier family 17 (acidic sugar transporter), member 5
Homo sapiens ENSG00000179520   solute carrier family 17 (vesicular glutamate transporter), member 8
Homo sapiens ENSG00000091664   solute carrier family 17 (vesicular glutamate transporter), member 6
Homo sapiens ENSG00000104888   solute carrier family 17 (vesicular glutamate transporter), member 7
Loa Loa (eye worm) LOAG_15519   major facilitator superfamily transporter
Loa Loa (eye worm) LOAG_14776   hypothetical protein
Loa Loa (eye worm) LOAG_15257   major facilitator superfamily transporter
Loa Loa (eye worm) LOAG_15629   hypothetical protein
Loa Loa (eye worm) LOAG_14465   hypothetical protein
Loa Loa (eye worm) LOAG_14988   hypothetical protein
Loa Loa (eye worm) LOAG_09395   major facilitator superfamily transporter
Loa Loa (eye worm) LOAG_08196   hypothetical protein
Loa Loa (eye worm) LOAG_03318   hypothetical protein
Loa Loa (eye worm) LOAG_03317   hypothetical protein
Loa Loa (eye worm) LOAG_15328   major facilitator superfamily transporter
Mus musculus ENSMUSG00000030500   solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Mus musculus ENSMUSG00000019935   solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Mus musculus ENSMUSG00000070570   solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Mus musculus ENSMUSG00000049624   solute carrier family 17 (anion/sugar transporter), member 5
Oryza sativa 4338960   Os05g0451100
Oryza sativa 4326905   Os01g0279700
Oryza sativa 4347913   Os09g0570400
Onchocerca volvulus OVOC5166  
Onchocerca volvulus OVOC8999   Uncharacterized transporter homolog
Onchocerca volvulus OVOC8259   Putative solute carrier family 17, member 7
Schistosoma japonicum Sjp_0074430   ko:K08193 MFS transporter, ACS family, solute carrier family 17, putative
Schistosoma japonicum Sjp_0074420   Vesicular glutamate transporter 2, putative
Schistosoma mansoni Smp_129060   solute carrier family 17 member 7 (vesicular glutamate transporter
Schmidtea mediterranea mk4.041737.01  
Schmidtea mediterranea mk4.004156.02  
Schmidtea mediterranea mk4.007610.01   Vesicular glutamate transporter
Schmidtea mediterranea mk4.000139.00  
Schmidtea mediterranea mk4.020272.00   Sialin
Schmidtea mediterranea mk4.006013.02  
Schmidtea mediterranea mk4.001687.05  
Schmidtea mediterranea mk4.000418.09  
Schmidtea mediterranea mk4.000418.10  
Schmidtea mediterranea mk4.000139.04  

Essentiality

Bm1_40175 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2789 Escherichia coli non-essential goodall
b3691 Escherichia coli non-essential goodall
CELE_ZK512.6 Caenorhabditis elegans larval arrest wormbase
CELE_ZK512.6 Caenorhabditis elegans slow growth wormbase
CELE_C38C10.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Vesicular glutamate transporter 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus Quinolone resistance protein norA 388 aa 22.6% 367 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_40175 (Brugia malayi), Major Facilitator Superfamily protein
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