Detailed view for Bm1_43690

Basic information

TDR Targets ID: 237206
Brugia malayi, nol5a protein
Source Database / ID:  GenBank

pI: 9.1712 | Length (AA): 603 | MW (Da): 68028 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01798   snoRNA binding domain, fibrillarin
PF08156   NOP5NT (NUC127) domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 414 5gip (A) 3 376 33.00 0 1 0.904375 0.57
36 414 3nmu (A) 11 371 32.00 0 1 0.936624 0.35
72 407 5gip (A) 33 373 34.00 0 1 0.894714 0.38
285 410 3gqu (A) 243 365 45.00 0 1 0.632155 -0.56
444 571 5j0l (A) 4 131 13.00 0.47 0.01 0.461772 -1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127848)

Species Accession Gene Product
Arabidopsis thaliana AT1G56110   nucleolar protein NOP56-like protein
Arabidopsis thaliana AT3G12860   NOP56-like pre RNA processing ribonucleoprotein
Babesia bovis BBOV_IV010840   nucleolar protein Nop56, putative
Brugia malayi Bm1_43690   nol5a protein
Candida albicans CaO19.7569   similar to S. cerevisiae SIK1 (YLR197W) nucleolar component of Box C/D snoRNPs
Caenorhabditis elegans CELE_K07C5.4   Protein K07C5.4
Cryptosporidium hominis Chro.20013   hypothetical protein
Cryptosporidium parvum cgd2_50   SIK1 nucleolar protein Nop56
Dictyostelium discoideum DDB_G0285679   NOP5 family protein
Drosophila melanogaster Dmel_CG13849   CG13849 gene product from transcript CG13849-RA
Echinococcus granulosus EgrG_000671800   nucleolar protein 56
Entamoeba histolytica EHI_122740   nucleolar protein Nop56, putative
Echinococcus multilocularis EmuJ_000671600   nucleolar protein 56
Echinococcus multilocularis EmuJ_000671800   nucleolar protein 56
Giardia lamblia GL50803_10577   Nucleolar protein NOP5
Homo sapiens ENSG00000101361   NOP56 ribonucleoprotein
Leishmania braziliensis LbrM.10.0210   nucleolar protein, putative
Leishmania donovani LdBPK_100210.1   nucleolar protein 56, putative
Leishmania infantum LinJ.10.0210   nucleolar protein, putative
Leishmania major LmjF.10.0210   nucleolar protein, putative
Leishmania mexicana LmxM.10.0210   nucleolar protein, putative
Loa Loa (eye worm) LOAG_03596   nol5a protein
Mus musculus ENSMUSG00000027405   NOP56 ribonucleoprotein
Neospora caninum NCLIV_065270   hypothetical protein
Oryza sativa 4332851   Os03g0352300
Onchocerca volvulus OVOC10611   Uncharacterized NOP5 family protein homolog
Plasmodium berghei PBANKA_0929600   nucleolar protein 56, putative
Plasmodium falciparum PF3D7_1118500   nucleolar protein 56, putative
Plasmodium knowlesi PKNH_0916200   nucleolar protein 56, putative
Plasmodium vivax PVX_091560   pre-RNA processing ribonucleoprotein, putative
Plasmodium yoelii PY00908   similar to S. cerevisiae SIK1
Saccharomyces cerevisiae YLR197W   snoRNP complex protein NOP56
Schistosoma japonicum Sjp_0076200   Nucleolar protein 5A, putative
Schistosoma mansoni Smp_048660   nucleolar protein NOP56
Schmidtea mediterranea mk4.002851.00   Nucleolar protein 56
Schmidtea mediterranea mk4.030703.00   Uncharacterized NOP5 family protein
Schmidtea mediterranea mk4.009358.00   Uncharacterized NOP5 family protein
Trypanosoma brucei gambiense Tbg972.8.3470   nucleolar protein, putative
Trypanosoma brucei Tb927.8.3750   nucleolar protein 56, putative
Trypanosoma congolense TcIL3000_8_3610   nucleolar protein 56, putative
Trypanosoma cruzi TcCLB.506189.10   nucleolar protein, putative
Toxoplasma gondii TGME49_247470   nucleolar protein, putative
Theileria parva TP01_0747   hypothetical protein, conserved
Trichomonas vaginalis TVAG_371980   prp31, putative

Essentiality

Bm1_43690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.3750 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.3750 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.3750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.3750 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K07C5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07C5.4 Caenorhabditis elegans larval arrest wormbase
CELE_K07C5.4 Caenorhabditis elegans larval lethal wormbase
CELE_K07C5.4 Caenorhabditis elegans slow growth wormbase
CELE_K07C5.4 Caenorhabditis elegans sterile wormbase
YLR197W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0929600 Plasmodium berghei Essential plasmo
TGME49_247470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_43690 (Brugia malayi), nol5a protein
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