Detailed view for Bm1_08890

Basic information

TDR Targets ID: 237459
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 10.5193 | Length (AA): 116 | MW (Da): 13305 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00472   RF-1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003747   translation release factor activity  
GO:0006415   translational termination  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 112 1rq0 (A) 193 306 29.00 0 0.99 1.20208 0.26
5 69 2rsm (A) 49 113 43.00 0.000000021 1 1.12514 -0.43
8 87 2ihr (1) 226 294 43.00 0.000017 1 1.09296 -0.31
37 110 4wij (A) 500 576 14.00 0.29 0 0.799731 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129206)

Species Accession Gene Product
Babesia bovis BBOV_IV005260   conserved hypothetical protein
Brugia malayi Bm1_08890   hypothetical protein
Candida albicans CaO19.5488   similar to S. cerevisiae YLR281C
Candida albicans CaO19.12943   similar to S. cerevisiae YLR281C
Caenorhabditis elegans CELE_T23B5.4   Protein T23B5.4, isoform B
Drosophila melanogaster Dmel_CG30100   CG30100 gene product from transcript CG30100-RA
Echinococcus granulosus EgrG_000185900   peptide chain release factor corf
Echinococcus multilocularis EmuJ_000185900   peptide chain release factor corf mitochondrial polypeptide chain release factor
Homo sapiens ENSG00000130921   chromosome 12 open reading frame 65
Leishmania braziliensis LbrM.30.3570   hypothetical protein, conserved
Leishmania donovani LdBPK_303600.1   RF-1 domain containing protein, putative
Leishmania infantum LinJ.30.3600   hypothetical protein, conserved
Leishmania major LmjF.30.3540   hypothetical protein, conserved
Leishmania mexicana LmxM.29.3540   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08838   hypothetical protein
Mus musculus ENSMUSG00000047635   RIKEN cDNA 2810006K23 gene
Onchocerca volvulus OVOC3962   Putative peptide chain release factor C12orf65, mitochondrial
Plasmodium berghei PBANKA_1007300   peptide chain release factor 2, putative
Plasmodium falciparum PF3D7_0409700   peptide chain release factor 2
Plasmodium knowlesi PKNH_0307800   peptide chain release factor 2, putative
Plasmodium vivax PVX_000760   hypothetical protein, conserved
Plasmodium yoelii PY04089   hypothetical protein
Saccharomyces cerevisiae YLR281C   hypothetical protein
Schistosoma japonicum Sjp_0213390   similar to Uncharacterized protein C12orf65, putative
Schistosoma mansoni Smp_079810   hypothetical protein
Schmidtea mediterranea mk4.000724.04   Probable peptide chain release factor C12orf65, mitochondrial
Trypanosoma brucei gambiense Tbg972.6.4740   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.4940   RF-1 domain containing protein, putative
Trypanosoma congolense TcIL3000_6_4360   RF-1 domain containing protein, putative
Trypanosoma cruzi TcCLB.506945.180   RF-1 domain containing protein, putative
Toxoplasma gondii TGME49_206360   peptidyl-tRNA hydrolase domain-containing protein
Theileria parva TP01_0213   hypothetical protein

Essentiality

Bm1_08890 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.4940 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.4940 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.6.4940 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1007300 Plasmodium berghei Dispensable plasmo
TGME49_206360 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_08890 (Brugia malayi), hypothetical protein
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