Detailed view for LmjF.35.0210

Basic information

TDR Targets ID: 23749
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.4785 | Length (AA): 73 | MW (Da): 8685 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06842   Protein of unknown function (DUF1242)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 71 2xnd (J) 43 73 35.00 0.7 0.01 0.437958 3.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129312)

Species Accession Gene Product
Arabidopsis thaliana AT5G20165   hypothetical protein
Cryptosporidium parvum cgd3_1420   conserved small protein
Dictyostelium discoideum DDB_G0289451   TMEM167 family protein
Drosophila melanogaster Dmel_CG14199   kish
Echinococcus granulosus EgrG_000069290   conserved hypothetical transmembrane protein
Echinococcus multilocularis EmuJ_000069290   conserved hypothetical transmembrane protein
Homo sapiens ENSG00000174695   transmembrane protein 167A
Leishmania braziliensis LbrM.34.0250   hypothetical protein, conserved
Leishmania donovani LdBPK_350210.1   Protein of unknown function (DUF1242), putative
Leishmania infantum LinJ.35.0210   hypothetical protein, conserved
Leishmania major LmjF.35.0210   hypothetical protein, conserved
Leishmania mexicana LmxM.34.0210   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_15791   hypothetical protein
Mus musculus 101055841   predicted gene 28601
Mus musculus 66074   transmembrane protein 167
Neospora caninum NCLIV_056800   hypothetical protein, conserved
Oryza sativa 4338222   Os05g0251500
Oryza sativa 4329089   Os02g0299600
Plasmodium berghei PBANKA_0835900   protein kish, putative
Plasmodium falciparum PF3D7_0935100   protein kish, putative
Plasmodium knowlesi PKNH_0733800   protein kish, putative
Plasmodium vivax PVX_086962   conserved protein, unknown function
Saccharomyces cerevisiae YNL024C-A   Ksh1p
Schistosoma japonicum Sjp_0201580   Transmembrane protein 167 precursor, putative
Schistosoma mansoni Smp_028410   Transmembrane protein 167A
Trypanosoma brucei gambiense Tbg972.10.5150   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.4140   Protein of unknown function (DUF1242), putative
Trypanosoma cruzi TcCLB.511467.13   Protein of unknown function (DUF1242), putative
Trypanosoma cruzi TcCLB.503453.4   Protein of unknown function (DUF1242), putative
Toxoplasma gondii TGME49_313530   transmembrane protein 167, putative

Essentiality

LmjF.35.0210 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.4140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.4140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.4140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.4140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YNL024C-A Saccharomyces cerevisiae inviable yeastgenome
TGME49_313530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.0210 (Leishmania major), hypothetical protein, conserved
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