Detailed view for Bm1_55385

Basic information

TDR Targets ID: 237619
Brugia malayi, 40S ribosomal protein S12
Source Database / ID:  GenBank

pI: 7.0421 | Length (AA): 143 | MW (Da): 15864 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01248   Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 141 4kzy (M) 9 132 65.00 0 1 1.63323 -0.28
19 123 2czw (A) 13 122 31.00 0 1 1.13707 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127261)

Species Accession Gene Product
Arabidopsis thaliana AT1G15930   40S ribosomal protein S12-1
Arabidopsis thaliana AT2G32060   40S ribosomal protein S12-2
Babesia bovis BBOV_III001100   40S ribosomal protein S12, putative
Brugia malayi Bm1_55385   40S ribosomal protein S12
Candida albicans CaO19.14077   likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12
Candida albicans CaO19.6785   likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12
Caenorhabditis elegans CELE_F54E7.2   Protein RPS-12
Cryptosporidium hominis Chro.50479   ribosomal protein S12
Cryptosporidium parvum cgd5_3740   40S ribosomal protein S12. pelota RNA binding domain containing protein
Dictyostelium discoideum DDB_G0284237   40S ribosomal protein S12
Drosophila melanogaster Dmel_CG11271   Ribosomal protein S12
Echinococcus granulosus EgrG_000209000   40S ribosomal protein S12
Entamoeba histolytica EHI_111760   40S ribosomal protein S12, putative
Entamoeba histolytica EHI_153330   40S ribosomal protein S12, putative
Echinococcus multilocularis EmuJ_000209000   ribosomal protein S12
Giardia lamblia GL50803_33862   Ribosomal protein S12
Homo sapiens 6206   ribosomal protein S12
Leishmania braziliensis LbrM.13.0390   40S ribosomal protein S12, putative
Leishmania donovani LdBPK_130460.1   40S ribosomal protein S12, putative
Leishmania infantum LinJ.13.0460   40S ribosomal protein S12, putative
Leishmania major LmjF.13.0570   40S ribosomal protein S12, putative
Leishmania mexicana LmxM.13.0570   40S ribosomal protein S12, putative
Loa Loa (eye worm) LOAG_05517   40S ribosomal protein S12
Mus musculus 100862223   predicted gene, 21571
Mus musculus ENSMUSG00000061983   ribosomal protein S12
Neospora caninum NCLIV_020360   40S ribosomal protein S12, related
Oryza sativa 4342771   Os07g0229900
Oryza sativa 4342408   Os07g0150200
Plasmodium berghei PBANKA_0405400   40S ribosomal protein S12, putative
Plasmodium falciparum PF3D7_0307100   40S ribosomal protein S12, putative
Plasmodium knowlesi PKNH_0835600   40S ribosomal protein S12, putative
Plasmodium vivax PVX_119475   40S ribosomal protein S12, putative
Plasmodium yoelii PY05755   40S ribosomal protein S12
Saccharomyces cerevisiae YOR369C   ribosomal 40S subunit protein S12
Schistosoma japonicum Sjp_0040720   ko:K02951 small subunit ribosomal protein S12e, putative
Schistosoma mansoni Smp_060090.2   40S ribosomal protein S12
Schmidtea mediterranea mk4.008691.01  
Schmidtea mediterranea mk4.003775.00  
Trypanosoma brucei gambiense Tbg972.11.4910   40S ribosomal protein S12, putative
Trypanosoma brucei Tb927.11.4290   40S ribosomal protein S12
Trypanosoma congolense TcIL3000.11.4340   40S ribosomal protein S12, putative
Trypanosoma cruzi TcCLB.503395.50   40S ribosomal protein S12, putative
Trypanosoma cruzi TcCLB.506181.59   40S ribosomal protein S12, putative
Toxoplasma gondii TGME49_205340   ribosomal protein RPS12
Theileria parva TP03_0717   40S ribosomal protein S12, putative
Trichomonas vaginalis TVAG_464050   40S ribosomal protein S12, putative
Trichomonas vaginalis TVAG_010250   40S ribosomal protein S12, putative
Trichomonas vaginalis TVAG_120740   40S ribosomal protein S12, putative
Trichomonas vaginalis TVAG_120980   40S ribosomal protein S12, putative
Trichomonas vaginalis TVAG_224610   40S ribosomal protein S12, putative

Essentiality

Bm1_55385 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1830 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.1830 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.1830 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1830 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F54E7.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F54E7.2 Caenorhabditis elegans larval arrest wormbase
CELE_F54E7.2 Caenorhabditis elegans larval lethal wormbase
CELE_F54E7.2 Caenorhabditis elegans slow growth wormbase
CELE_F54E7.2 Caenorhabditis elegans sterile wormbase
PBANKA_0405400 Plasmodium berghei Essential plasmo
TGME49_205340 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_55385 (Brugia malayi), 40S ribosomal protein S12
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