pI: 7.2452 |
Length (AA): 237 |
MW (Da): 26938 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 174 | 5szj (A) | 1 | 175 | 75.00 | 0.000000048 | 1 | 1.72458 | -1.5 |
3 | 175 | 2fu5 (C) | 3 | 175 | 85.00 | 0 | 1 | 1.52336 | -0.53 |
9 | 208 | 3m1i (A) | 13 | 217 | 26.00 | 0 | 1 | 1.20308 | -0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127321)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G53610 | RAB GTPase-8 |
Arabidopsis thaliana | AT5G59840 | Ras-related small GTP-binding family protein |
Arabidopsis thaliana | AT3G46060 | small GTP-binding protein ARA3 |
Arabidopsis thaliana | AT3G09900 | RAB GTPase-like protein E1E |
Brugia malayi | Bm1_47575 | Rab family protein 8 |
Brugia malayi | Bm1_48835 | Ras-related protein Rab-10 |
Candida albicans | CaO19.10103 | Ras-related protein similar to S. cerevisiae SEC4 (YFL005W) secretory vesicle associated Rab GTPase that binds to Sec15p and is |
Candida albicans | CaO19.2571 | Ras-related protein similar to S. cerevisiae SEC4 (YFL005W) secretory vesicle associated Rab GTPase that binds to Sec15p and is |
Caenorhabditis elegans | CELE_T23H2.5 | Protein RAB-10 |
Caenorhabditis elegans | CELE_D1037.4 | Protein RAB-8 |
Dictyostelium discoideum | DDB_G0276399 | Rab GTPase |
Dictyostelium discoideum | DDB_G0280043 | Rab GTPase |
Drosophila melanogaster | Dmel_CG17060 | CG17060 gene product from transcript CG17060-RA |
Drosophila melanogaster | Dmel_CG8287 | CG8287 gene product from transcript CG8287-RA |
Echinococcus granulosus | EgrG_001003300 | ras protein rab 8b |
Echinococcus granulosus | EgrG_001176700 | ras protein Rab 10 |
Entamoeba histolytica | EHI_199820 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_001003300 | ras protein rab 8b |
Echinococcus multilocularis | EmuJ_001176700 | ras protein Rab 10 |
Homo sapiens | ENSG00000166128 | RAB8B, member RAS oncogene family |
Homo sapiens | 4218 | RAB8A, member RAS oncogene family |
Homo sapiens | ENSG00000084733 | RAB10, member RAS oncogene family |
Loa Loa (eye worm) | LOAG_10079 | RAB-10 protein |
Mus musculus | ENSMUSG00000036943 | RAB8B, member RAS oncogene family |
Mus musculus | ENSMUSG00000020671 | RAB10, member RAS oncogene family |
Mus musculus | 17274 | RAB8A, member RAS oncogene family |
Oryza sativa | 4334590 | Os03g0819900 |
Oryza sativa | 4339021 | Os05g0461300 |
Oryza sativa | 4342802 | Os07g0239400 |
Saccharomyces cerevisiae | YFL005W | Rab family GTPase SEC4 |
Schistosoma japonicum | Sjp_0041080 | ko:K07976 Rab family, other, putative |
Schistosoma japonicum | Sjp_0023950 | ko:K07976 Rab family, other, putative |
Schistosoma mansoni | Smp_104670 | rab15 13 10 1 35 5 and |
Schistosoma mansoni | Smp_014660.1 | rab-related GTP-binding protein |
Schistosoma mansoni | Smp_014660.2 | rab-related GTP-binding protein |
Schmidtea mediterranea | mk4.002894.00 | |
Schmidtea mediterranea | mk4.000086.02 | |
Schmidtea mediterranea | mk4.003653.02 | |
Schmidtea mediterranea | mk4.019657.00 | |
Schmidtea mediterranea | mk4.002257.00 | |
Schmidtea mediterranea | mk4.000504.06 | |
Schmidtea mediterranea | mk4.016674.01 | Ras-related protein Rab-8B |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_D1037.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T23H2.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T23H2.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T23H2.5 | Caenorhabditis elegans | sterile | wormbase |
YFL005W | Saccharomyces cerevisiae | inviable | yeastgenome |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.