Detailed view for Bm1_51505

Basic information

TDR Targets ID: 237810
Brugia malayi, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
Source Database / ID:  GenBank

pI: 7.7168 | Length (AA): 1312 | MW (Da): 151444 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00387   Phosphatidylinositol-specific phospholipase C, Y domain
PF00388   Phosphatidylinositol-specific phospholipase C, X domain
PF06631   Protein of unknown function (DUF1154)
PF09279   Phosphoinositide-specific phospholipase C, efhand-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0004629   phospholipase C activity  
GO:0004435   phosphoinositide phospholipase C activity  
GO:0008081   phosphoric diester hydrolase activity  
GO:0005509   calcium ion binding  
GO:0007242   intracellular signaling cascade  
GO:0007165   signal transduction  
GO:0006629   lipid metabolic process  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 999 3qr0 (A) 12 809 45.00 0 1 0.802622 0.72
12 143 1mai (A) 17 130 21.00 0.0000023 0.35 0.13151 -0.14
844 967 3m7f (B) 123 283 33.00 0.52 0.89 0.433812 -0.3
1052 1293 4tql (A) 10 238 26.00 0.000028 0.59 0.426751 -0.53
1056 1304 1jad (A) 14 224 24.00 0.00006 1 0.315087 -0.05
1248 1309 5hmo (A) 819 880 23.00 0.13 0.02 0.432156 -1.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128749)

Species Accession Gene Product
Brugia malayi Bm1_51790   Phosphatidylinositol-specific phospholipase C, X domain containing protein
Brugia malayi Bm1_51505   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
Caenorhabditis elegans CELE_B0348.4   Protein EGL-8, isoform C
Drosophila melanogaster Dmel_CG4574   Phospholipase C at 21C
Drosophila melanogaster Dmel_CG3620   no receptor potential A
Echinococcus granulosus EgrG_000803800   1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4
Echinococcus multilocularis EmuJ_000803800   1 phosphatidylinositol 4,5 bisphosphate
Homo sapiens ENSG00000137841   phospholipase C, beta 2
Homo sapiens ENSG00000101333   phospholipase C, beta 4
Homo sapiens ENSG00000182621   phospholipase C, beta 1 (phosphoinositide-specific)
Homo sapiens ENSG00000149782   phospholipase C, beta 3 (phosphatidylinositol-specific)
Loa Loa (eye worm) LOAG_03717   hypothetical protein
Loa Loa (eye worm) LOAG_00068   Plcb4 protein
Mus musculus ENSMUSG00000040061   phospholipase C, beta 2
Mus musculus ENSMUSG00000039943   phospholipase C, beta 4
Mus musculus ENSMUSG00000024960   phospholipase C, beta 3
Mus musculus ENSMUSG00000051177   phospholipase C, beta 1
Schistosoma japonicum Sjp_0095060   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4, putative
Schistosoma japonicum Sjp_0048500   ko:K05858 phospholipase C, beta, putative
Schistosoma japonicum Sjp_0098420   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4, putative
Schistosoma mansoni Smp_146330   phospholipase C beta
Schmidtea mediterranea mk4.000405.07  
Schmidtea mediterranea mk4.001147.05   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Schmidtea mediterranea mk4.020057.01   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Schmidtea mediterranea mk4.018098.00  
Schmidtea mediterranea mk4.000405.08   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Schmidtea mediterranea mk4.018124.00  
Schmidtea mediterranea mk4.007689.02  
Schmidtea mediterranea mk4.006856.01   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Schmidtea mediterranea mk4.001147.06  

Essentiality

Bm1_51505 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0348.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0348.4 Caenorhabditis elegans slow growth wormbase
CELE_B0348.4 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_51505 (Brugia malayi), 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
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