pI: 6.6172 |
Length (AA): 218 |
MW (Da): 24457 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_131714)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_00420 | hypothetical protein |
Brugia malayi | Bm1_03665 | hypothetical protein |
Candida albicans | CaO19.13861 | transport of nitrogen-regulated permeases |
Candida albicans | CaO19.6508 | transport of nitrogen-regulated permeases |
Candida albicans | CaO19_6508 | hypothetical protein |
Caenorhabditis elegans | CELE_F22D3.2 | Protein FLCN-1, isoform C |
Dictyostelium discoideum | DDB_G0281111 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8616 | Birt-Hogg-Dube homolog |
Echinococcus granulosus | EgrG_000479900 | folliculin |
Echinococcus multilocularis | EmuJ_000479900 | folliculin |
Homo sapiens | ENSG00000154803 | folliculin |
Loa Loa (eye worm) | LOAG_03765 | hypothetical protein |
Mus musculus | ENSMUSG00000032633 | folliculin |
Saccharomyces cerevisiae | YGR057C | Lst7p |
Schistosoma japonicum | Sjp_0042000 | expressed protein |
Schistosoma mansoni | Smp_176040 | eukaryotictranslation initiation factor |
Schmidtea mediterranea | mk4.005885.02 | Eukaryotictranslation initiation factor,putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.