pI: 4.5566 |
Length (AA): 401 |
MW (Da): 44670 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 401 | 4am6 (A) | 260 | 878 | 17.00 | 0 | 1 | 0.528225 | 0.94 |
9 | 392 | 4cbu (A) | 4 | 367 | 34.00 | 0 | 1 | 1.16561 | 0.31 |
10 | 400 | 1yag (A) | 4 | 374 | 30.00 | 0 | 1 | 1.24316 | 0.1 |
11 | 400 | 5i9e (B) | 5 | 374 | 34.00 | 0 | 1 | 1.17757 | 0.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128301)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G18450 | actin-related protein 4 |
Babesia bovis | BBOV_I004010 | actin, putative |
Brugia malayi | Bm1_15575 | actin-like protein 6B |
Candida albicans | CaO19.13069 | potential NuA4 histone acetyltransferase complex component |
Caenorhabditis elegans | CELE_ZK616.4 | Protein SWSN-6 |
Cryptosporidium hominis | Chro.80259 | BRG1/brm-associated factor 53A |
Cryptosporidium parvum | cgd8_2200 | BRG1/brm-associated factor 53A like actin |
Dictyostelium discoideum | DDB_G0280887 | actin related protein 4 |
Drosophila melanogaster | Dmel_CG6546 | Brahma associated protein 55kD |
Echinococcus granulosus | EgrG_001191400 | actin 6a |
Echinococcus multilocularis | EmuJ_001191400 | actin 6a |
Homo sapiens | ENSG00000136518 | actin-like 6A |
Homo sapiens | ENSG00000077080 | actin-like 6B |
Loa Loa (eye worm) | LOAG_02121 | actin |
Mus musculus | ENSMUSG00000029712 | actin-like 6B |
Mus musculus | ENSMUSG00000027671 | actin-like 6A |
Neospora caninum | NCLIV_028320 | actin-like family protein ARP4a, putative |
Neospora caninum | NCLIV_007590 | actin-like family protein ARP4a, putative |
Oryza sativa | 4344621 | Os08g0137200 |
Plasmodium berghei | PBANKA_1020600 | actin-related protein, putative |
Plasmodium falciparum | PF3D7_1422800 | actin-related protein, putative |
Plasmodium knowlesi | PKNH_1335200 | actin-related protein, putative |
Plasmodium vivax | PVX_085340 | actin, putative |
Plasmodium yoelii | PY00021 | Actin |
Saccharomyces cerevisiae | YJL081C | Arp4p |
Schistosoma japonicum | Sjp_0092370 | Actin-like protein 6A, putative |
Schistosoma mansoni | Smp_063040 | hypothetical protein |
Schistosoma mansoni | Smp_184940 | hypothetical protein |
Schmidtea mediterranea | mk4.001411.03 | Actin-like protein 6, acl6 |
Toxoplasma gondii | TGME49_258050 | actin like protein ALP2a |
Toxoplasma gondii | TGME49_253040 | actin-related protein ARP4A |
Theileria parva | TP02_0707 | actin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_ZK616.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK616.4 | Caenorhabditis elegans | larval arrest | wormbase |
YJL081C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1020600 | Plasmodium berghei | Essential | plasmo |
TGME49_253040 | Toxoplasma gondii | Probably essential | sidik |
TGME49_258050 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Xenopus laevis | beta-actin | 375 aa | 29.5% | 403 aa | Compounds | References |