pI: 5.1988 |
Length (AA): 349 |
MW (Da): 40600 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 312 | 1jk0 (A) | 60 | 359 | 57.00 | 0 | 1 | 1.74 | -2.23 |
30 | 307 | 1w68 (A) | 70 | 348 | 62.00 | 0 | 1 | 1.78 | -2.66 |
18 | 312 | 2o1z (A) | 17 | 311 | 94.00 | 0 | 1 | 2.05487 | -1.98 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late schizont, late trophozoite, Oocyst, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | merozoite, sporozoite, late ring, Sporozoite, Female Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, early ring, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs. | Otto TD |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_126823)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G23580 | ribonucleoside-diphosphate reductase small chain A |
Arabidopsis thaliana | AT3G27060 | ribonucleoside-diphosphate reductase small chain C |
Babesia bovis | BBOV_IV010610 | ribonucleoside-diphosphate reductase small subunit, putative |
Brugia malayi | Bm1_34225 | ribonucleotide reductase 2 |
Candida albicans | CaO19.1868 | small subunit of ribonucleotide reductase |
Candida albicans | CaO19.9424 | small subunit of ribonucleotide reductase |
Candida albicans | CaO19.5801 | subunit of ribonucleotide reductase |
Candida albicans | CaO19.13223 | subunit of ribonucleotide reductase |
Caenorhabditis elegans | CELE_F58F9.1 | Protein F58F9.1 |
Caenorhabditis elegans | CELE_C03C10.3 | Protein RNR-2 |
Cryptosporidium hominis | Chro.60090 | ribonucleotide reductase R2 subunit |
Cryptosporidium parvum | cgd6_690 | ribonucleotide reductase small subunit, duplicated adjacent gene |
Chlamydia trachomatis | CT_828 | ribonucleoside-diphosphate reductase subunit beta |
Dictyostelium discoideum | DDB_G0274021 | ribonucleoside-diphosphate reductase |
Dictyostelium discoideum | DDB_G0272616 | ribonucleoside-diphosphate reductase |
Drosophila melanogaster | Dmel_CG8975 | Ribonucleoside diphosphate reductase small subunit |
Escherichia coli | b2235 | ribonucleoside-diphosphate reductase 1, beta subunit, ferritin-like protein |
Echinococcus granulosus | EgrG_000437000 | ribonucleoside diphosphate reductase subunit |
Echinococcus multilocularis | EmuJ_000437000 | ribonucleoside diphosphate reductase subunit |
Homo sapiens | ENSG00000171848 | ribonucleotide reductase M2 |
Homo sapiens | ENSG00000048392 | ribonucleotide reductase M2 B (TP53 inducible) |
Leishmania braziliensis | LbrM.27.2230 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania braziliensis | LbrM.22.1170 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania infantum | LinJ.27.1970 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania infantum | LinJ.22.1110 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania major | LmjF.22.1290 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania major | LmjF.27.2050 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania mexicana | LmxM.22.1290 | ribonucleoside-diphosphate reductase small chain, putative |
Leishmania mexicana | LmxM.27.2050 | ribonucleoside-diphosphate reductase small chain, putative |
Loa Loa (eye worm) | LOAG_04964 | ribonucleotide reductase M2 B |
Mus musculus | ENSMUSG00000022292 | ribonucleotide reductase M2 B (TP53 inducible) |
Mus musculus | ENSMUSG00000020649 | ribonucleotide reductase M2 |
Mycobacterium tuberculosis | Rv0233 | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) |
Mycobacterium tuberculosis | Rv1981c | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) |
Neospora caninum | NCLIV_052980 | hypothetical protein |
Oryza sativa | 4339981 | Os06g0127900 |
Oryza sativa | 9266846 | Os06g0257450 |
Plasmodium berghei | PBANKA_1036600 | ribonucleoside-diphosphate reductase small chain, putative |
Plasmodium falciparum | PF3D7_1405600 | ribonucleoside-diphosphate reductase small chain, putative |
Plasmodium knowlesi | PKNH_1352500 | ribonucleoside-diphosphate reductase small chain, putative |
Plasmodium vivax | PVX_086155 | ribonucleoside-diphosphate reductase small chain, putative |
Plasmodium yoelii | PY03671 | Ribonucleotide reductase, small chain |
Saccharomyces cerevisiae | YJL026W | ribonucleotide-diphosphate reductase subunit RNR2 |
Schistosoma japonicum | Sjp_0071060 | ko:K00526 ribonucleoside-diphosphate reductase beta chain [EC1.17.4.1B], putative |
Schistosoma mansoni | Smp_055890 | ribonucleoside-diphosphate reductase small chain |
Schmidtea mediterranea | mk4.022157.01 | Ribonucleoside-diphosphate reductase subunit M2 |
Schmidtea mediterranea | mk4.014717.02 | Ribonucleoside-diphosphate reductase subunit M2 |
Schmidtea mediterranea | mk4.003858.03 | |
Schmidtea mediterranea | mk4.036403.00 | Ribonucleoside diphosphate reductase subunit M2-2 |
Schmidtea mediterranea | mk4.001969.00 | Ribonucleoside-diphosphate reductase subunit M2 |
Schmidtea mediterranea | mk4.036428.00 | Ribonucleoside diphosphate reductase subunit M2-2 |
Schmidtea mediterranea | mk4.023330.00 | Ribonucleoside diphosphate reductase subunit M2 |
Schmidtea mediterranea | mk4.034835.01 | Ribonucleoside-diphosphate reductase subunit M2 |
Schmidtea mediterranea | mk4.005023.00 | |
Schmidtea mediterranea | mk4.019490.00 | Ribonucleoside-diphosphate reductase subunit M2 |
Trypanosoma brucei gambiense | Tbg972.11.14280 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei gambiense | Tbg972.11.14290 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei gambiense | Tbg972.11.14270 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei | Tb927.11.12800 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei | Tb927.11.12810 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei | Tb927.11.12820 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma brucei | Tb11.v5.0288 | ribonucleoside-diphosphate reductase small chain, putative |
Trypanosoma congolense | TcIL3000_0_15160 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma congolense | TcIL3000_0_35830 | ribonucleoside-diphosphate reductase small chain |
Trypanosoma cruzi | TcCLB.506621.30 | ribonucleoside-diphosphate reductase small chain, putative |
Trypanosoma cruzi | TcCLB.511555.80 | ribonucleoside-diphosphate reductase small chain, putative |
Toxoplasma gondii | TGME49_207060 | ribonucleoside-diphosphate reductase small subunit |
Treponema pallidum | TP0053 | ribonucleotide-diphosphate reductase subunit beta |
Theileria parva | TP01_0725 | ribonucleotide-diphosphate reductase small subunit, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0267 | ribonucleotide-diphosphate reductase subunit beta |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu235 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb11.v4.0004 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.v4.0004 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.v4.0004 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.v4.0004 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2235 | Escherichia coli | essential | goodall |
CELE_C03C10.3 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C03C10.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C03C10.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C03C10.3 | Caenorhabditis elegans | sterile | wormbase |
YJL026W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1036600 | Plasmodium berghei | Essential | plasmo |
TGME49_207060 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased time (PATO:0000716) | multi-cellular organism (CARO:0000012) | bloodstream stage (PLO:0040) | inferred from anti-sense experiment (ECO:0000018) | Plasmodium falciparum | No drug identifiers listed for this gene. |
Annotator: | saralph@unimelb.edu.au. | Comment: | 012/Mar/09. | References: | 8552672 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 1
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ribonucleotide reductase M2 | Compounds | References |
Homo sapiens | ribonucleotide reductase M2 B (TP53 inducible) | Compounds | References |
1 literature reference was collected for this gene.