Detailed view for Bm1_14035

Basic information

TDR Targets ID: 238618
Brugia malayi, SCP-like extracellular protein
Source Database / ID:  GenBank

pI: 6.8032 | Length (AA): 220 | MW (Da): 25089 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00188   Cysteine-rich secretory protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005576   extracellular region  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 219 4g2u (A) 1 200 26.00 0.0013 1 1.13467 0.17
17 218 1u53 (A) 0 189 37.00 0 1 1.37558 -0.63
21 196 1qnx (A) 33 203 28.00 0.000000000012 1 1.092 0.02
23 195 1qnx (A) 35 202 29.00 0 1 1.13686 -0.64
26 131 4jkq (A) 466 534 41.00 0.12 0.08 0.261218 1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 6ANY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131713)

Species Accession Gene Product
Arabidopsis thaliana AT4G25790   allergen V5/Tpx-1-related family protein
Arabidopsis thaliana AT5G57625   CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein
Brugia malayi Bm1_14035   SCP-like extracellular protein
Brugia malayi Bm1_14040   venom allergen antigen-like protein 1
Brugia malayi Bm1_14045   SCP-like extracellular protein
Caenorhabditis elegans CELE_ZK384.1   Protein SCL-19
Echinococcus granulosus EgrG_000766600   peptidase inhibitor 16
Echinococcus granulosus EgrG_001155900   cysteine rich secretory protein LCCL
Echinococcus multilocularis EmuJ_001155900   cysteine rich secretory protein LCCL
Homo sapiens ENSG00000121005   cysteine-rich secretory protein LCCL domain containing 1
Homo sapiens ENSG00000103196   cysteine-rich secretory protein LCCL domain containing 2
Loa Loa (eye worm) LOAG_16208   hypothetical protein
Loa Loa (eye worm) LOAG_15941   hypothetical protein
Loa Loa (eye worm) LOAG_14904   hypothetical protein
Loa Loa (eye worm) LOAG_11328   activation-associated secreted protein-1
Loa Loa (eye worm) LOAG_16302   hypothetical protein
Loa Loa (eye worm) LOAG_15455   activation-associated secreted protein-1
Loa Loa (eye worm) LOAG_15306   hypothetical protein
Mus musculus ENSMUSG00000031825   cysteine-rich secretory protein LCCL domain containing 2
Mus musculus ENSMUSG00000025776   cysteine-rich secretory protein LCCL domain containing 1
Oryza sativa 4330952   Os02g0786500
Onchocerca volvulus OVOC7395  
Onchocerca volvulus OVOC9570  
Onchocerca volvulus OVOC9348  
Onchocerca volvulus OVOC9575  
Onchocerca volvulus OVOC9555  
Onchocerca volvulus OVOC9559  
Onchocerca volvulus OVOC7440  
Schmidtea mediterranea mk4.004819.03  
Schmidtea mediterranea mk4.023868.00  
Schmidtea mediterranea mk4.001981.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_14035 (Brugia malayi), SCP-like extracellular protein
Title for this comment
Comment