Detailed view for Bm1_52135

Basic information

TDR Targets ID: 238648
Brugia malayi, TRP channel protein nanchung
Source Database / ID:  GenBank

pI: 9.411 | Length (AA): 776 | MW (Da): 89222 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12796   Ankyrin repeats (3 copies)
PF13606   Ankyrin repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005515   protein binding  
GO:0005216   ion channel activity  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
116 352 2f37 (A) 87 317 22.00 0 1 0.480012 0.41
146 709 5iwk (A) 71 607 30.00 0 0.91 0.778704 1.39
181 352 2eta (A) 149 318 41.00 0.0000000000062 1 0.386549 0.05
263 350 2zgd (A) 24 110 34.00 0 1 0.673002 -1.62
263 355 2rfm (A) 65 157 28.00 0.0041 1 0.655745 -1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137704)

Species Accession Gene Product
Brugia malayi Bm1_52135   TRP channel protein nanchung
Caenorhabditis elegans CELE_F28H7.10   Protein OCR-1, isoform A
Caenorhabditis elegans CELE_T09A12.3   Protein OCR-2
Caenorhabditis elegans CELE_F28H7.10a   Protein OCR-1, isoform B
Caenorhabditis elegans CELE_T10B10.7   Protein OCR-3
Drosophila melanogaster Dmel_CG5842   nanchung
Loa Loa (eye worm) LOAG_14505   hypothetical protein
Loa Loa (eye worm) LOAG_15333   hypothetical protein
Loa Loa (eye worm) LOAG_12723   hypothetical protein
Loa Loa (eye worm) LOAG_05731   hypothetical protein
Loa Loa (eye worm) LOAG_15576   hypothetical protein
Loa Loa (eye worm) LOAG_15822   hypothetical protein
Onchocerca volvulus OVOC6101b   Nanchung homolog
Onchocerca volvulus OVOC6509a   Nanchung homolog
Onchocerca volvulus OVOC6101a   Nanchung homolog
Schmidtea mediterranea mk4.000540.12   Nanchung
Schmidtea mediterranea mk4.000540.13   Nanchung

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Transient receptor potential cation channel subfamily V member 2 761 aa 27.5% 625 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_52135 (Brugia malayi), TRP channel protein nanchung
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