pI: 6.4606 |
Length (AA): 205 |
MW (Da): 22848 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 176 | 3sfv (A) | 1 | 176 | 86.00 | 0 | 1 | 1.94844 | -1.39 |
6 | 199 | 2bcg (Y) | 3 | 196 | 70.00 | 0.0000000017 | 1 | 1.87734 | -1.5 |
14 | 115 | 4fmc (F) | 14 | 115 | 96.00 | 0 | 1 | 0.958461 | 1.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127310)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G11730 | Ras-related protein RABD1 |
Arabidopsis thaliana | AT4G17530 | RAB GTPase homolog 1C |
Arabidopsis thaliana | AT5G47200 | ras-related protein RABD2b |
Arabidopsis thaliana | AT1G02130 | Ras-related protein RABD2A |
Babesia bovis | BBOV_III000780 | Rab1b |
Brugia malayi | Bm1_52380 | Ras-related protein Rab-1A |
Candida albicans | CaO19.3052 | likely ras family GTPase involved in docking of ER vesicles to Golgi |
Candida albicans | CaO19.10570 | likely ras family GTPase involved in docking of ER vesicles to Golgi |
Caenorhabditis elegans | CELE_C39F7.4 | Protein RAB-1 |
Cryptosporidium hominis | Chro.60374 | small GTP binding protein rab1a |
Cryptosporidium parvum | cgd6_3220 | RAS small GTpases RIC1/ypt1 |
Dictyostelium discoideum | DDB_G0283757 | Rab GTPase |
Dictyostelium discoideum | DDB_G0284985 | Rab GTPase |
Dictyostelium discoideum | DDB_G0277867 | Rab GTPase |
Drosophila melanogaster | Dmel_CG3320 | CG3320 gene product from transcript CG3320-RA |
Echinococcus granulosus | EgrG_000255300 | small GTP binding protein |
Echinococcus granulosus | EgrG_000548300 | small GTP binding protein |
Entamoeba histolytica | EHI_108610 | Rab family GTPase |
Entamoeba histolytica | EHI_146510 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_000255300 | small GTP binding protein |
Echinococcus multilocularis | EmuJ_000548300 | small GTP binding protein |
Giardia lamblia | GL50803_9558 | Rab1a |
Homo sapiens | ENSG00000174903 | RAB1B, member RAS oncogene family |
Homo sapiens | ENSG00000138069 | RAB1A, member RAS oncogene family |
Leishmania braziliensis | LbrM.27.0850 | small GTP-binding protein Rab1, putative |
Leishmania donovani | LdBPK_270620.1 | ras-related protein RAB1A, putative |
Leishmania infantum | LinJ.27.0620 | small GTP-binding protein Rab1, putative |
Leishmania major | LmjF.27.0760 | small GTP-binding protein Rab1, putative |
Leishmania mexicana | LmxM.27.0760 | small GTP-binding protein Rab1, putative |
Loa Loa (eye worm) | LOAG_03820 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05538 | Rab1E |
Mus musculus | ENSMUSG00000020149 | RAB1, member RAS oncogene family |
Mus musculus | ENSMUSG00000024870 | RAB1B, member RAS oncogene family |
Neospora caninum | NCLIV_051820 | hypothetical protein |
Oryza sativa | 4325347 | Os01g0179700 |
Oryza sativa | 4324675 | Os01g0558600 |
Oryza sativa | 4330181 | Os02g0653800 |
Plasmodium berghei | PBANKA_1112300 | ras-related protein Rab-1B, putative |
Plasmodium falciparum | PF3D7_0512600 | ras-related protein Rab-1B |
Plasmodium knowlesi | PKNH_1020500 | ras-related protein Rab-1B, putative |
Plasmodium vivax | PVX_080610 | ras-related protein Rab-1B, putative |
Plasmodium yoelii | PY04604 | putative GTPase |
Saccharomyces cerevisiae | YFL038C | Rab family GTPase YPT1 |
Schistosoma japonicum | Sjp_0044620 | IPR013753,Ras,domain-containing |
Schistosoma japonicum | Sjp_0044630 | Ras-like GTP-binding protein YPT1, putative |
Schistosoma japonicum | Sjp_0219250 | Trafficking protein particle complex subunit 6B, putative |
Schistosoma mansoni | Smp_072290 | rab15 13 10 1 35 5 and |
Schmidtea mediterranea | mk4.002844.04 | FI01544p |
Schmidtea mediterranea | mk4.001775.03 | Putative rab15, 13, 10, 1, 35, 5, and |
Schmidtea mediterranea | mk4.001287.03 | Putative rab15, 13, 10, 1, 35, 5, and |
Schmidtea mediterranea | mk4.003474.01 | Putative rab15, 13, 10, 1, 35, 5, and |
Schmidtea mediterranea | mk4.000617.00 | FI01544p |
Schmidtea mediterranea | mk4.003653.01 | Putative rab15, 13, 10, 1, 35, 5, and |
Trypanosoma brucei gambiense | Tbg972.8.510 | small GTP-binding protein Rab1, putative |
Trypanosoma brucei | Tb927.8.890 | Ras-related protein Rab1A |
Trypanosoma congolense | TcIL3000_0_14810 | Ras-related protein RAB1A1, putative |
Trypanosoma congolense | TcIL3000_0_39520 | Ras-related protein RAB1A2, putative |
Trypanosoma cruzi | TcCLB.503715.30 | ras-related protein RAB1A, putative |
Toxoplasma gondii | TGME49_214770 | small GTP binding protein rab1a, putative |
Theileria parva | TP03_0775 | small GTP-binding protein rab1 |
Trichomonas vaginalis | TVAG_383350 | RAB-2,4 |
Trichomonas vaginalis | TVAG_070500 | Rab7g protein, putative |
Trichomonas vaginalis | TVAG_047800 | Rab11, putative |
Trichomonas vaginalis | TVAG_379850 | Rab32, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.890 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.890 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C39F7.4 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C39F7.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C39F7.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C39F7.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C39F7.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C39F7.4 | Caenorhabditis elegans | sterile | wormbase |
YFL038C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_214770 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.