Detailed view for Bm1_29370

Basic information

TDR Targets ID: 238817
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 6.855 | Length (AA): 525 | MW (Da): 60974 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03999   Microtubule associated protein (MAP65/ASE1 family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008017   microtubule binding  
GO:0000226   microtubule cytoskeleton organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 411 4l6y (A) 10 448 25.00 0 1 0.722871 1.19
289 413 2i1k (A) 301 451 29.00 0.29 0.59 0.425395 0.05
299 418 3nrx (A) 4 130 29.00 0.00000043 0.59 0.550871 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128835)

Species Accession Gene Product
Arabidopsis thaliana AT4G26760   microtubule-associated protein 65-2
Arabidopsis thaliana AT3G60840   microtubule-associated protein 65-4
Arabidopsis thaliana AT5G62250   microtubule-associated protein 65-9
Arabidopsis thaliana AT5G55230   microtubule-associated protein 65-1
Brugia malayi Bm1_29320   hypothetical protein
Brugia malayi Bm1_29370   hypothetical protein
Candida albicans CaO19.7377   microtubule binding
Caenorhabditis elegans CELE_Y34D9A.4   Protein SPD-1
Dictyostelium discoideum DDB_G0280249   hypothetical protein
Dictyostelium discoideum DDB_G0284219   hypothetical protein
Drosophila melanogaster Dmel_CG1655   sister of feo
Drosophila melanogaster Dmel_CG11207   fascetto
Echinococcus granulosus EgrG_000375900   protein regulator of cytokinesis 1
Echinococcus granulosus EgrG_000738100   protein regulator of cytokinesis 1
Echinococcus multilocularis EmuJ_000738100   protein regulator of cytokinesis 1
Echinococcus multilocularis EmuJ_000375900   protein regulator of cytokinesis 1
Homo sapiens ENSG00000198901   protein regulator of cytokinesis 1
Loa Loa (eye worm) LOAG_10658   hypothetical protein
Mus musculus ENSMUSG00000038943   protein regulator of cytokinesis 1
Oryza sativa 4330548   Os02g0720200
Oryza sativa 4333924   Os03g0719000
Oryza sativa 4328154   Os02g0126300
Oryza sativa 4340849   Os06g0308300
Oryza sativa 4341510   Os06g0611000
Saccharomyces cerevisiae YOR058C   Ase1p
Schistosoma japonicum Sjp_0078950   Protein regulator of cytokinesis 1, putative
Schistosoma japonicum Sjp_0028290   Protein regulator of cytokinesis 1, putative
Schistosoma japonicum Sjp_0085070   Protein regulator of cytokinesis 1, putative
Schistosoma mansoni Smp_016870   protein regulator of cytokinesis 1 prc1
Schistosoma mansoni Smp_169210   protein regulator of cytokinesis 1 prc1-related
Schmidtea mediterranea mk4.000119.01  
Schmidtea mediterranea mk4.001765.02   Protein regulator of cytokinesis 1 prc1-related
Trichomonas vaginalis TVAG_072400   protein regulator of cytokinesis, putative
Trichomonas vaginalis TVAG_505020   protein regulator of cytokinesis, putative
Trichomonas vaginalis TVAG_171600   protein regulator of cytokinesis 1 prc1, putative
Trichomonas vaginalis TVAG_195920   protein regulator of cytokinesis 1 prc1, putative
Trichomonas vaginalis TVAG_413720   protein regulator of cytokinesis, putative
Trichomonas vaginalis TVAG_570540   conserved hypothetical protein

Essentiality

Bm1_29370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y34D9A.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_29370 (Brugia malayi), hypothetical protein
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