Detailed view for Bm1_33310

Basic information

TDR Targets ID: 238976
Brugia malayi, PDZ-domain protein scribble
Source Database / ID:  GenBank

pI: 5.9428 | Length (AA): 1245 | MW (Da): 135641 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 422 2z7x (A) 42 469 28.00 0.0000013 1 0.493682 0.51
58 121 2jqd (A) 62 128 44.00 0.32 0.87 0.442606 -0.2
728 797 1wha (A) 21 97 59.00 0.00000000036 1 0.659425 -0.59
838 934 2i1n (A) 128 221 44.00 0.000000000043 1 0.749112 -1.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130662)

Species Accession Gene Product
Brugia malayi Bm1_33310   PDZ-domain protein scribble
Caenorhabditis elegans CELE_F26D11.11   Protein LET-413, isoform A
Drosophila melanogaster Dmel_CG43398   scribbled
Echinococcus granulosus EgrG_000988700   cell polarity protein
Echinococcus multilocularis EmuJ_000988700   cell polarity protein leucine rich repeat
Homo sapiens ENSG00000137269   leucine rich repeat containing 1
Homo sapiens ENSG00000180900   scribbled planar cell polarity protein
Loa Loa (eye worm) LOAG_14052   hypothetical protein
Loa Loa (eye worm) LOAG_06880   PDZ-domain-containing protein scribble
Mus musculus ENSMUSG00000022568   scribbled homolog (Drosophila)
Mus musculus ENSMUSG00000032352   leucine rich repeat containing 1
Oryza sativa 4349464   Os10g0572300
Schistosoma japonicum Sjp_0014670   ko:K06095 multiple PDZ domain protein, putative
Schistosoma japonicum Sjp_0313830   expressed protein
Schistosoma japonicum Sjp_0078320   expressed protein
Schistosoma japonicum Sjp_0078330   expressed protein
Schistosoma japonicum Sjp_0122540   IPR001611,Leucine-rich repeat,domain-containing
Schistosoma japonicum Sjp_0076460   Protein lap4, putative
Schistosoma japonicum Sjp_0014650   expressed protein
Schistosoma japonicum Sjp_0078310   Protein lap4, putative
Schistosoma mansoni Smp_104030.3   leucine-rich repeat protein
Schistosoma mansoni Smp_104030.2   leucine-rich repeat protein
Schmidtea mediterranea mk4.017239.01   Protein lap4
Schmidtea mediterranea mk4.029048.00  
Schmidtea mediterranea mk4.017239.00  
Schmidtea mediterranea mk4.000686.03  
Schmidtea mediterranea mk4.006142.00   SHOC2
Schmidtea mediterranea mk4.018001.00  
Schmidtea mediterranea mk4.025254.00  
Schmidtea mediterranea mk4.016524.02   Protein lap4

Essentiality

Bm1_33310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F26D11.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_F26D11.11 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_33310 (Brugia malayi), PDZ-domain protein scribble
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