Detailed view for Bm1_30540

Basic information

TDR Targets ID: 239050
Brugia malayi, Glycosyl hydrolases family 38 protein
Source Database / ID:  GenBank

pI: 6.3349 | Length (AA): 1049 | MW (Da): 120170 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01074   Glycosyl hydrolases family 38 N-terminal domain
PF07748   Glycosyl hydrolases family 38 C-terminal domain
PF09261   Alpha mannosidase middle domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030246   carbohydrate binding  
GO:0015923   mannosidase activity  
GO:0008270   zinc ion binding  
GO:0004559   alpha-mannosidase activity  
GO:0003824   catalytic activity  
GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

Other glycan degradation (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
245 1046 2wyh (A) 0 900 20.00 0 1 0.739138 0.59
246 1009 2wyh (A) 0 879 19.00 0 1 0.777113 0.58
256 503 1k1x (A) 2 256 17.00 0 1 0.407016 -0.24
826 905 4ozx (A) 186 269 35.00 0.57 0.42 0.135963 1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130172)

Species Accession Gene Product
Brugia malayi Bm1_30540   Glycosyl hydrolases family 38 protein
Candida albicans CaO19.10284   vacuolar alpha mannosidase
Candida albicans CaO19.2768   vacuolar alpha mannosidase
Dictyostelium discoideum DDB_G0287577   hypothetical protein
Homo sapiens ENSG00000140400   mannosidase, alpha, class 2C, member 1
Loa Loa (eye worm) LOAG_07825   glycosyl hydrolase family 38 protein
Mus musculus ENSMUSG00000032295   mannosidase, alpha, class 2C, member 1
Mycobacterium ulcerans MUL_0737   alpha-mannosidase
Saccharomyces cerevisiae YGL156W   Ams1p
Schmidtea mediterranea mk4.002395.05   Alpha-mannosidase 2C1
Schmidtea mediterranea mk4.002395.06   Alpha-mannosidase 2C1
Trichomonas vaginalis TVAG_123030   alpha-mannosidase 2c1, putative
Trichomonas vaginalis TVAG_123020   alpha-mannosidase 2c1, putative
Trichomonas vaginalis TVAG_030610   alpha-mannosidase 2c1, putative
Trichomonas vaginalis TVAG_371840   alpha-mannosidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Alpha-mannosidase 2C1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0326 0.3389 0.239
0.0144 0.4234 0
0.0091 0.2833 0.2833
0.0054 0.3793 0
0.0365 0.3282 0.3176
0.0054 0.3793 0
0.0054 0.3793 0
0.0054 0.3793 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_30540 (Brugia malayi), Glycosyl hydrolases family 38 protein
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