Detailed view for Bm1_52725

Basic information

TDR Targets ID: 239083
Brugia malayi, Leo1-like protein
Source Database / ID:  GenBank

pI: 4.2917 | Length (AA): 476 | MW (Da): 53971 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04004   Leo1-like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016593   Cdc73/Paf1 complex  
GO:0016570   histone modification  
GO:0006368   RNA elongation from RNA polymerase II promoter  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 476 4igg (B) 257 753 10.00 0 0.03 1.0393 0.09
4 161 5cwh (A) 2 157 10.00 0 0.01 0.539233 -1.68
114 291 4m6t (A) 10 192 35.00 0.000000021 0.46 0.67375 0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129431)

Species Accession Gene Product
Arabidopsis thaliana AT5G61150   protein VERNALIZATION INDEPENDENCE 4
Brugia malayi Bm1_52725   Leo1-like protein
Candida albicans CaO19_7116   hypothetical protein
Candida albicans CaO19.7116   similar to S. cerevisiae RNA polymerase II-associated Paf1 complex component LEO1
Caenorhabditis elegans CELE_B0035.11   Protein B0035.11
Dictyostelium discoideum DDB_G0286051   RNA polymerase II complex component
Drosophila melanogaster Dmel_CG1433   Another transcription unit
Echinococcus granulosus EgrG_001036400   RNA polymerase associated protein LEO1
Echinococcus multilocularis EmuJ_001036400   RNA polymerase associated protein LEO1
Homo sapiens ENSG00000166477   Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_00036   hypothetical protein
Mus musculus ENSMUSG00000042487   Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Mus musculus 666190   predicted gene 7972
Oryza sativa 4352631   Os12g0579000
Oryza sativa 4342220   Os07g0109600
Saccharomyces cerevisiae YOR123C   Leo1p
Schistosoma japonicum Sjp_0302070   RNA polymerase-associated protein LEO1, putative
Schistosoma mansoni Smp_172160   senescence downregulated leo1-like
Schmidtea mediterranea mk4.000310.02   RNA polymerase-associated protein LEO1

Essentiality

Bm1_52725 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0035.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0035.11 Caenorhabditis elegans larval arrest wormbase
CELE_B0035.11 Caenorhabditis elegans slow growth wormbase
CELE_B0035.11 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_52725 (Brugia malayi), Leo1-like protein
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