Detailed view for Bm1_30605
Basic information
Brugia malayi, RWD domain containing protein
Source Database / ID: GenBank
pI: 6.896 |
Length (AA): 1208 |
MW (Da): 137393 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
GO:0005524 ATP binding
GO:0005515 protein binding
GO:0004713 protein tyrosine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0006468 protein amino acid phosphorylation
Metabolic Pathways
Structural information
Modbase 3D models:
There are 14 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 14 | 151 | 1ukx (A) | 1 | 136 | 35.00 | 0 | 1 | 0.598138 | -0.93 |
| 29 | 147 | 2dmf (A) | 15 | 128 | 28.00 | 0.000000018 | 1 | 0.49641 | -0.77 |
| 138 | 204 | 5hmo (A) | 809 | 876 | 21.00 | 0.1 | 0.01 | 0.316364 | -0.79 |
| 471 | 1040 | 4w7p (A) | 6 | 395 | 28.00 | 0 | 0.86 | 0.0707543 | 2.08 |
| 543 | 983 | 3n9x (A) | 12 | 384 | 24.00 | 0 | 1 | -0.148034 | 1.44 |
| 547 | 1118 | 4yzb (A) | 16 | 448 | 24.00 | 0 | 1 | 0.17981 | 1.42 |
| 728 | 999 | 4uy9 (A) | 179 | 434 | 23.00 | 0 | 1 | 0.391066 | -0.25 |
| 730 | 967 | 4b9d (A) | 41 | 258 | 30.00 | 0 | 1 | 0.51292 | -0.55 |
| 733 | 994 | 3lij (A) | 108 | 347 | 27.00 | 0 | 1 | 0.426787 | 0.01 |
| 768 | 871 | 2c47 (A) | 117 | 220 | 25.00 | 0.00000063 | 0.3 | 0.147993 | 0.99 |
| 794 | 908 | 1j1b (A) | 162 | 259 | 47.00 | 0.0000011 | 0.88 | 0.367099 | 0.25 |
| 796 | 1015 | 1q8y (A) | 272 | 726 | 32.00 | 0.0051 | 0.76 | 0.158019 | 0.89 |
| 1025 | 1194 | 4g84 (A) | 67 | 233 | 24.00 | 0 | 0.86 | 0.256628 | 1.01 |
| 1025 | 1182 | 1wu7 (A) | 17 | 172 | 20.00 | 0.0066 | 0.38 | 0.201695 | 0.98 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129525)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G59410 | eIF2alpha kinase |
| Babesia bovis | BBOV_II006890 | Ser/Thr protein kinase, putative |
| Brugia malayi | Bm1_30605 | RWD domain containing protein |
| Candida albicans | CaO19_6913 | hypothetical protein |
| Candida albicans | CaO19.6913 | likely protein kinase similar to S. cerevisiae GCN2 (YDR283C) eukaryotic initiation factor 2 alpha kinase |
| Caenorhabditis elegans | CELE_Y81G3A.3 | Protein GCN-2, isoform B |
| Dictyostelium discoideum | DDB_G0276829 | GCN2 subfamily protein kinase |
| Dictyostelium discoideum | DDB_G0272837 | GCN2 subfamily protein kinase |
| Drosophila melanogaster | Dmel_CG1609 | CG1609 gene product from transcript CG1609-RA |
| Echinococcus granulosus | EgrG_000527600 | eukaryotic translation initiation factor 2 alpha |
| Echinococcus multilocularis | EmuJ_000527600 | eukaryotic translation initiation factor 2 alpha |
| Homo sapiens | ENSG00000128829 | eukaryotic translation initiation factor 2 alpha kinase 4 |
| Loa Loa (eye worm) | LOAG_10609 | hypothetical protein |
| Mus musculus | ENSMUSG00000005102 | eukaryotic translation initiation factor 2 alpha kinase 4 |
| Oryza sativa | 4336257 | Os04g0492600 |
| Saccharomyces cerevisiae | YDR283C | Gcn2p |
| Schistosoma japonicum | Sjp_0071960 | ko:K08860 eukaryotic translation initiation factor 2-alpha kinase, putative |
| Schistosoma mansoni | Smp_079390 | protein kinase |
| Schmidtea mediterranea | mk4.010831.00 | Eukaryotic translation initiation factor 2-alpha kinase 4 |
| Trichomonas vaginalis | TVAG_074170 | STE family protein kinase |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | eukaryotic translation initiation factor 2 alpha kinase 4 | Compounds | References |
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 30.5% | 164 aa | Compounds | References |
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References
1 literature reference was collected for this gene.