pI: 9.4516 |
Length (AA): 464 |
MW (Da): 50653 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 454 | 4c0s (A) | 4 | 455 | 84.00 | 0 | 1 | 2.02168 | -1.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126631)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G60390 | elongation factor 1-alpha 4 |
Arabidopsis thaliana | AT1G07920 | elongation factor 1-alpha 3 |
Arabidopsis thaliana | AT1G07940 | elongation factor 1-alpha 1 |
Babesia bovis | BBOV_IV010630 | elongation factor 1-alpha |
Babesia bovis | BBOV_IV010620 | elongation factor 1-alpha |
Brugia malayi | Bm1_27170 | elongation factor 1-alpha (EF-1-alpha) |
Brugia malayi | Bm1_09680 | elongation factor 1-alpha |
Candida albicans | CaO19.9009 | One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes |
Candida albicans | CaO19.12585 | One of 3 closely related translation elongation factor EF-1 alpha genes |
Candida albicans | CaO19.8012 | One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes |
Candida albicans | CaO19.382 | One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes |
Candida albicans | CaO19.1435 | One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes |
Candida albicans | CaO19.5119 | One of 3 closely related translation elongation factor EF-1 alpha genes |
Caenorhabditis elegans | CELE_R03G5.1 | Protein EEF-1A.2, isoform C |
Caenorhabditis elegans | CELE_F31E3.5 | Protein EEF-1A.1 |
Cryptosporidium hominis | Chro.60459 | elongation factor 1-alpha (EF-1-ALPHA) |
Cryptosporidium parvum | cgd6_3990 | elongation factor 1 alpha |
Dictyostelium discoideum | DDB_G0269136 | elongation factor 1 alpha |
Dictyostelium discoideum | DDB_G0269134 | elongation factor 1 alpha |
Drosophila melanogaster | Dmel_CG1873 | Elongation factor 1alpha100E |
Drosophila melanogaster | Dmel_CG8280 | Elongation factor 1alpha48D |
Echinococcus granulosus | EgrG_000982200 | elongation factor 1 alpha |
Entamoeba histolytica | EHI_102170 | elongation factor 1-alpha 1 |
Entamoeba histolytica | EHI_011210 | elongation factor 1-alpha 1 |
Entamoeba histolytica | EHI_052400 | elongation factor 1-alpha 1 |
Echinococcus multilocularis | EmuJ_000982200 | elongation factor 1 alpha |
Giardia lamblia | GL50803_112304 | Elongation factor 1-alpha |
Giardia lamblia | GL50803_112312 | Elongation factor 1-alpha |
Homo sapiens | ENSG00000156508 | eukaryotic translation elongation factor 1 alpha 1 |
Homo sapiens | ENSG00000101210 | eukaryotic translation elongation factor 1 alpha 2 |
Leishmania braziliensis | LbrM.17.0090 | elongation factor 1-alpha |
Leishmania donovani | LdBPK_170170.1 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0200 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0100 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0110 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0090 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0170 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0180 | elongation factor 1-alpha |
Leishmania infantum | LinJ.17.0190 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0081 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0085 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0083 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0082 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0084 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0080 | elongation factor 1-alpha |
Leishmania major | LmjF.17.0086 | elongation factor 1-alpha |
Leishmania mexicana | LmxM.17.0082 | elongation factor 1-alpha |
Leishmania mexicana | LmxM.17.0085 | elongation factor 1-alpha |
Leishmania mexicana | LmxM.17.0081 | elongation factor 1-alpha |
Leishmania mexicana | LmxM.17.0080 | elongation factor 1-alpha |
Loa Loa (eye worm) | LOAG_06320 | elongation factor 1-alpha |
Loa Loa (eye worm) | LOAG_08753 | eukaryotic translation elongation factor 1A |
Mus musculus | ENSMUSG00000037742 | eukaryotic translation elongation factor 1 alpha 1 |
Mus musculus | ENSMUSG00000016349 | eukaryotic translation elongation factor 1 alpha 2 |
Neospora caninum | NCLIV_001670 | Elongation factor 1-alpha, related |
Neospora caninum | NCLIV_014180 | Elongation factor 1-alpha, related |
Oryza sativa | 4331810 | Os03g0177400 |
Oryza sativa | 4331811 | Os03g0177500 |
Oryza sativa | 4331813 | Os03g0178000 |
Oryza sativa | 4331812 | Os03g0177900 |
Onchocerca volvulus | OVOC11940 |
|
Onchocerca volvulus | OVOC1671 |
|
Plasmodium berghei | PBANKA_1133300 | elongation factor 1-alpha |
Plasmodium berghei | PBANKA_1133400 | elongation factor 1-alpha |
Plasmodium falciparum | PF3D7_1357000 | elongation factor 1-alpha |
Plasmodium falciparum | PF3D7_1357100 | elongation factor 1-alpha |
Plasmodium knowlesi | PKNH_1114400 | elongation factor 1-alpha, putative |
Plasmodium knowlesi | PKNH_1114500 | elongation factor 1-alpha |
Plasmodium vivax | PVX_114832 | elongation factor 1-alpha, putative |
Plasmodium yoelii | PY00362 | translation elongation factor EF-1, subunit alpha |
Plasmodium yoelii | PY00361 | translation elongation factor EF-1, subunit alpha |
Plasmodium yoelii | PY02338 | translation elongation factor EF-1, subunit alpha |
Saccharomyces cerevisiae | YPR080W | translation elongation factor EF-1 alpha |
Saccharomyces cerevisiae | YBR118W | translation elongation factor EF-1 alpha |
Schistosoma japonicum | Sjp_0054280 | ko:K03231 elongation factor EF-1 alpha subunit, putative |
Schistosoma mansoni | Smp_099870 | elongation factor 1-alpha (ef-1-alpha) |
Schmidtea mediterranea | mk4.000421.02 | |
Schmidtea mediterranea | mk4.000076.22 | |
Schmidtea mediterranea | mk4.000753.07 | |
Schmidtea mediterranea | mk4.000969.05 | |
Schmidtea mediterranea | mk4.020804.02 | |
Schmidtea mediterranea | mk4.000498.08 | |
Schmidtea mediterranea | mk4.000094.10 | |
Schmidtea mediterranea | mk4.002287.01 | |
Trypanosoma brucei gambiense | Tbg972.10.2530 | elongation factor 1-alpha, putative |
Trypanosoma brucei gambiense | Tbg972.10.2550 | elongation factor 1-alpha, putative |
Trypanosoma brucei | Tb927.10.2110 | elongation factor 1-alpha |
Trypanosoma brucei | Tb927.10.2100 | elongation factor 1-alpha |
Trypanosoma brucei | Tb927.10.2090 | elongation factor 1-alpha |
Trypanosoma congolense | TcIL3000_10_1740 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.510119.9 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.511369.20 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.511369.30 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.511367.370 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.511369.10 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.510119.20 | elongation factor 1-alpha, putative |
Trypanosoma cruzi | TcCLB.511367.360 | elongation factor 1-alpha, putative |
Toxoplasma gondii | TGME49_294800 | elongation factor 1-alpha (EF-1-ALPHA), putative |
Toxoplasma gondii | TGME49_286420 | elongation factor 1-alpha (EF-1-ALPHA), putative |
Theileria parva | TP01_0726 | elongation factor 1 alpha, putative |
Trichomonas vaginalis | TVAG_463940 | translation factor, putative |
Trichomonas vaginalis | TVAG_354100 | elongation factor 1-alpha, putative |
Trichomonas vaginalis | TVAG_013320 | translation factor, putative |
Trichomonas vaginalis | TVAG_067400 | elongation factor 1-alpha, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2090 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.2090 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F31E3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F31E3.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F31E3.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F31E3.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F31E3.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_R03G5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R03G5.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R03G5.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_R03G5.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1133400 | Plasmodium berghei | Slow | plasmo |
TGME49_286420 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_294800 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_286420 | Toxoplasma gondii | Probably essential | sidik |
TGME49_294800 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | elongation factor 1-alpha | Compounds | References |
Homo sapiens | eukaryotic translation elongation factor 1 alpha 1 | Compounds | References |
Homo sapiens | eukaryotic translation elongation factor 1 alpha 2 | Compounds | References |