Detailed view for Bm1_38845

Basic information

TDR Targets ID: 239590
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 5.0108 | Length (AA): 2905 | MW (Da): 321835 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00632   HECT-domain (ubiquitin-transferase)
PF06701   Mib_herc2
PF07738   Sad1 / UNC-like C-terminal
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005488   binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0046872   metal ion binding  
GO:0016881   acid-amino acid ligase activity  
GO:0005515   protein binding  
GO:0016567   protein ubiquitination  
GO:0006464   protein modification process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 594 2q5d (B) 239 861 12.00 0 1 0.25251 0.5
8 208 5aei (A) 12 201 17.00 0.0000000021 1 0.337891 -1.34
53 779 2qna (A) 129 861 14.00 0 1 0.306358 0.35
372 493 3utm (A) 332 452 26.00 0.02 1 0.488497 -1.36
374 469 2rfm (A) 56 167 41.00 0.000016 1 0.469546 -0.96
392 473 5jhq (A) 237 322 43.00 0.0000075 1 0.586727 -0.78
544 678 3c5r (A) 0 545 13.00 0.15 0.1 0.0691716 0.12
553 691 5aq8 (A) 50 177 12.00 0.0086 0.23 0.128549 -0.43
1451 1531 3dkm (A) 1264 1341 47.00 0.00000012 0.97 0.571583 -0.92
1465 1521 4xi6 (A) 14 70 47.00 0.00028 1 0.588121 -0.78
2442 2903 5lp8 (A) 3947 4372 22.00 0 1 0.114736 0.69
2789 2899 5hps (A) 802 915 28.00 0 0.68 0.40631 -1
2818 2896 3pt3 (A) 2714 2790 38.00 0.3 0.67 0.349694 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132865)

Species Accession Gene Product
Brugia malayi Bm1_38845   hypothetical protein
Caenorhabditis elegans CELE_C34D4.14   Protein HECD-1
Drosophila melanogaster Dmel_CG5604   CG5604 gene product from transcript CG5604-RA
Echinococcus granulosus EgrG_000812800   E3 ubiquitin protein ligase HECTD1
Echinococcus granulosus EgrG_000326100   E3 ubiquitin protein ligase HECTD1
Echinococcus multilocularis EmuJ_000812800   E3 ubiquitin protein ligase HECTD1
Echinococcus multilocularis EmuJ_000326100   E3 ubiquitin protein ligase HECTD1
Homo sapiens ENSG00000092148   HECT domain containing E3 ubiquitin protein ligase 1
Loa Loa (eye worm) LOAG_00153   hypothetical protein
Mus musculus ENSMUSG00000035247   HECT domain containing 1
Schistosoma japonicum Sjp_0310270   E3 ubiquitin-protein ligase HECTD1, putative
Schistosoma japonicum Sjp_0047070   ko:K01931 hectd1; HECT domain containing 1 [EC:6.3.2.19], putative
Schistosoma mansoni Smp_169180   hypothetical protein
Schmidtea mediterranea mk4.038976.00   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.026199.00  
Schmidtea mediterranea mk4.008172.00  
Schmidtea mediterranea mk4.016371.00   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.017290.01  
Schmidtea mediterranea mk4.021439.00   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.028807.01  
Schmidtea mediterranea mk4.023323.00   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.021439.02   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.017290.03   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.009646.00   E3 ubiquitin-protein ligase HECTD1
Schmidtea mediterranea mk4.008857.00  

Essentiality

Bm1_38845 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C34D4.14 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_38845 (Brugia malayi), hypothetical protein
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