Detailed view for Bm1_28785

Basic information

TDR Targets ID: 239758
Brugia malayi, HIT zinc finger family protein
Source Database / ID:  GenBank

pI: 9.9067 | Length (AA): 174 | MW (Da): 20331 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04438   HIT zinc finger

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
128 169 2n95 (A) 0 41 33.00 0 0.46 0.501079 0.76
135 167 2od1 (A) 661 692 38.00 0.95 0.35 0.357855 1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130358)

Species Accession Gene Product
Arabidopsis thaliana AT5G37055   SWR1 complex subunit 6
Brugia malayi Bm1_28785   HIT zinc finger family protein
Caenorhabditis elegans CELE_CD4.7   Protein ZHIT-1, isoform A
Dictyostelium discoideum DDB_G0284961   hypothetical protein
Drosophila melanogaster Dmel_CG31917   CG31917 gene product from transcript CG31917-RA
Echinococcus granulosus EgrG_000231600   Zinc finger HIT domain containing protein 1
Echinococcus multilocularis EmuJ_000231600   Zinc finger HIT domain containing protein 1
Homo sapiens ENSG00000106400   zinc finger, HIT-type containing 1
Loa Loa (eye worm) LOAG_03510   HIT zinc finger family protein
Mus musculus ENSMUSG00000059518   zinc finger, HIT domain containing 1
Neospora caninum NCLIV_068270   hypothetical protein, conserved
Oryza sativa 4332920   Os03g0367800
Plasmodium berghei PBANKA_1026800   zinc finger protein, putative
Plasmodium falciparum PF3D7_1415900   zinc finger protein, putative
Plasmodium knowlesi PKNH_1342200   zinc finger protein, putative
Plasmodium vivax PVX_085655   zinc finger protein, putative
Plasmodium yoelii PY06970   hypothetical protein
Schistosoma japonicum Sjp_0208310   Zinc finger HIT domain-containing protein 1, putative
Schistosoma mansoni Smp_103830.2   hypothetical protein
Schistosoma mansoni Smp_103830.1   hypothetical protein
Schmidtea mediterranea mk4.003531.01  
Toxoplasma gondii TGME49_277680   hypothetical protein

Essentiality

Bm1_28785 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_277680 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_28785 (Brugia malayi), HIT zinc finger family protein
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