Detailed view for Bm1_50045

Basic information

TDR Targets ID: 239894
Brugia malayi, Homeobox domain containing protein
Source Database / ID:  GenBank

pI: 7.1664 | Length (AA): 1436 | MW (Da): 160202 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00046   Homeobox domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0005622   intracellular  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  
GO:0043565   sequence-specific DNA binding  
GO:0008270   zinc ion binding  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 80 4f6m (A) 521 581 25.00 0.099 0.36 0.346879 -0.29
21 67 2wbs (A) 430 482 43.00 0.66 0.97 0.35013 0.79
21 78 2lce (A) 18 74 37.00 0.009 0.92 0.46479 0.17
117 921 1tr2 (A) 45 837 11.00 0 1 0.554985 0.53
607 673 2da1 (A) 3 69 75.00 0 1 1.08906 -2.03
623 659 2e19 (A) 15 51 32.00 0.77 0.9 0.598166 -1.73
787 832 1p7i (B) 8 53 37.00 0.00045 1 0.688533 -2.2
1353 1385 2eoe (A) 3 35 36.00 0.12 0.57 0.39448 0.12
1353 1387 2ytj (A) 3 37 23.00 0.94 0.13 0.182873 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130502)

Species Accession Gene Product
Arabidopsis thaliana AT2G36610   homeobox-leucine zipper protein ATHB-22
Brugia malayi Bm1_50045   Homeobox domain containing protein
Caenorhabditis elegans CELE_ZC123.3   Protein ZFH-2
Drosophila melanogaster Dmel_CG1449   Zn finger homeodomain 2
Homo sapiens ENSG00000140836   zinc finger homeobox 3
Homo sapiens ENSG00000091656   zinc finger homeobox 4
Loa Loa (eye worm) LOAG_00628   hypothetical protein
Loa Loa (eye worm) LOAG_00632   hypothetical protein
Loa Loa (eye worm) LOAG_09377   homeobox domain-containing protein
Loa Loa (eye worm) LOAG_14250   hypothetical protein
Mus musculus ENSMUSG00000038872   zinc finger homeobox 3
Mus musculus ENSMUSG00000025255   zinc finger homeodomain 4
Onchocerca volvulus OVOC477  
Schistosoma japonicum Sjp_0108630   ko:K09380 zinc finger homeobox protein 4, putative
Schistosoma mansoni Smp_171420   hypothetical protein
Schmidtea mediterranea mk4.002961.01   Zinc finger protein 2
Schmidtea mediterranea mk4.001933.01  
Schmidtea mediterranea mk4.001933.00  

Essentiality

Bm1_50045 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZC123.3 Caenorhabditis elegans larval lethal wormbase
CELE_ZC123.3 Caenorhabditis elegans slow growth wormbase
CELE_ZC123.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_50045 (Brugia malayi), Homeobox domain containing protein
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