Detailed view for LmjF.35.0410

Basic information

TDR Targets ID: 23992
Leishmania major, 40S ribosomal protein S3A, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.9929 | Length (AA): 264 | MW (Da): 30008 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01015   Ribosomal S3Ae family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 236 4kzy (B) 19 233 41.00 0 1 1.33356 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126852)

Species Accession Gene Product
Arabidopsis thaliana AT4G34670   40S ribosomal protein S3a-2
Arabidopsis thaliana AT3G04840   40S ribosomal protein S3a-1
Babesia bovis BBOV_III001480   40S ribosomal protein S3Ae, putative
Brugia malayi Bm1_27225   40S ribosomal protein S3a
Candida albicans CaO19.10520   Ribosomal Protein 10, similar to S. cerevisiae RPS1B (YML063W) and RPS1A (YLR441C) cytosolic ribosomal small subunit protein S1
Candida albicans CaO19.3002   Ribosomal Protein 10, similar to S. cerevisiae RPS1B (YML063W) and RPS1A (YLR441C) cytosolic ribosomal small subunit protein S1
Caenorhabditis elegans CELE_F56F3.5   Protein RPS-1
Cryptosporidium hominis Chro.40360   40S ribosomal protein S3A
Cryptosporidium parvum cgd4_3160   putative 40S ribosomal protein S3A
Dictyostelium discoideum DDB_G0277345   40S ribosomal protein S3a
Drosophila melanogaster Dmel_CG2168   Ribosomal protein S3A
Echinococcus granulosus EgrG_001011600   ribosomal protein s3a
Entamoeba histolytica EHI_050280   40S ribosomal protein S3a, putative
Entamoeba histolytica EHI_065270   40S ribosomal protein S3a, putative
Entamoeba histolytica EHI_072040   40S ribosomal protein S3a, putative
Echinococcus multilocularis EmuJ_001011600   ribosomal protein s3a
Giardia lamblia GL50803_16265   Ribosomal protein S3a
Homo sapiens ENSG00000145425   ribosomal protein S3A
Leishmania braziliensis LbrM.34.0440   40S ribosomal protein S3A, putative
Leishmania braziliensis LbrM.34.0430   40S ribosomal protein S3A, putative
Leishmania donovani LdBPK_350400.1   40S ribosomal protein S3A, putative
Leishmania donovani LdBPK_350410.1   40S ribosomal protein S3A, putative
Leishmania infantum LinJ.35.0400   40S ribosomal protein S3A, putative
Leishmania infantum LinJ.35.0410   40S ribosomal protein S3A, putative
Leishmania major LmjF.35.0420   40S ribosomal protein S3A, putative
Leishmania major LmjF.35.0400   40S ribosomal protein S3A, putative
Leishmania major LmjF.35.0410   40S ribosomal protein S3A, putative
Leishmania mexicana LmxM.34.0400a  
Leishmania mexicana LmxM.34.0400b  
Leishmania mexicana LmxM.34.0420   40S ribosomal protein S3A, putative
Leishmania mexicana LmxM.34.0400   40S ribosomal protein S3A, putative
Loa Loa (eye worm) LOAG_05919   40S ribosomal protein S3a
Mus musculus ENSMUSG00000028081   ribosomal protein S3A1
Neospora caninum NCLIV_032660   hypothetical protein
Oryza sativa 4329042   Os02g0287000
Oryza sativa 4352048   Os12g0406200
Oryza sativa 4331966   Os03g0200500
Plasmodium berghei PBANKA_1215600   40S ribosomal protein S3A, putative
Plasmodium falciparum PF3D7_0322900   40S ribosomal protein S3A, putative
Plasmodium knowlesi PKNH_0817500   40S ribosomal protein S3A, putative
Plasmodium vivax PVX_095080   40S ribosomal protein S3A, putative
Plasmodium yoelii PY02291   40S ribosomal protein S3a-related
Plasmodium yoelii PY02290   40S ribosomal protein RP10-related
Saccharomyces cerevisiae YML063W   ribosomal 40S subunit protein S1B
Saccharomyces cerevisiae YLR441C   ribosomal 40S subunit protein S1A
Schistosoma japonicum Sjp_0077210   ko:K02984 small subunit ribosomal protein S3Ae, putative
Schistosoma mansoni Smp_073880.1   40S ribosomal protein S3A
Schistosoma mansoni Smp_073880.2   40S ribosomal protein S3A
Schmidtea mediterranea mk4.002118.04   40S ribosomal protein S3a
Schmidtea mediterranea mk4.002118.02   40S ribosomal protein S3a
Trypanosoma brucei gambiense Tbg972.10.4890   40S ribosomal protein S3A, putative
Trypanosoma brucei gambiense Tbg972.10.4900   40S ribosomal protein S3A, putative
Trypanosoma brucei Tb927.10.3940   40S ribosomal protein S3A, putative
Trypanosoma brucei Tb927.10.3930   40S ribosomal protein S3A, putative
Trypanosoma congolense TcIL3000_10_3260   40S ribosomal protein S3A, putative
Trypanosoma cruzi TcCLB.503635.59   40S ribosomal protein S3A, putative
Trypanosoma cruzi TcCLB.503635.68   40S ribosomal protein S3A, putative
Trypanosoma cruzi TcCLB.511001.18   40S ribosomal protein S3A, putative
Trypanosoma cruzi TcCLB.511001.9   40S ribosomal protein S3A, putative
Toxoplasma gondii TGME49_232710   ribosomal protein RPS3A
Theileria parva TP03_0697   40S ribosomal protein S3A, putative
Trichomonas vaginalis TVAG_142060   40S ribosomal protein S3a, putative
Trichomonas vaginalis TVAG_414510   40S ribosomal protein S3a, putative
Trichomonas vaginalis TVAG_348090   40S ribosomal protein S3a, putative
Trichomonas vaginalis TVAG_047460   40S ribosomal protein S3a, putative

Essentiality

LmjF.35.0410 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.3930 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.3930 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.3930 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.3930 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F56F3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F56F3.5 Caenorhabditis elegans larval arrest wormbase
CELE_F56F3.5 Caenorhabditis elegans slow growth wormbase
CELE_F56F3.5 Caenorhabditis elegans sterile wormbase
TGME49_232710 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.35.0410 (Leishmania major), 40S ribosomal protein S3A, putative
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