Detailed view for Bm1_17980

Basic information

TDR Targets ID: 240202
Brugia malayi, Arp2/3 complex component protein 1
Source Database / ID:  GenBank

pI: 5.3195 | Length (AA): 394 | MW (Da): 44860 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00022   Actin

Gene Ontology

Mouse over links to read term descriptions.
GO:0034314   Arp2/3 complex-mediated actin nucleation  
GO:0007015   actin filament organization  
GO:0005885   Arp2/3 protein complex  
GO:0005524   ATP binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 394 1k8k (A) 30 418 78.00 0 1 1.8868 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128269)

Species Accession Gene Product
Arabidopsis thaliana AT1G13180   actin-related protein 3
Brugia malayi Bm1_17980   Arp2/3 complex component protein 1
Candida albicans CaO19.2289   component of Arp2/3 protein complex
Candida albicans CaO19.9829   component of Arp2/3 protein complex
Caenorhabditis elegans CELE_Y71F9AL.16   Protein ARX-1
Dictyostelium discoideum DDB_G0283755   actin related protein 3
Drosophila melanogaster Dmel_CG7558   Actin-related protein 3
Echinococcus granulosus EgrG_000360500   ankyrin 23:unc44
Echinococcus granulosus EgrG_000292600   actin protein 3B
Entamoeba histolytica EHI_198930   Actin, putative
Echinococcus multilocularis EmuJ_000292600   actin protein 3B
Echinococcus multilocularis EmuJ_000360500   ankyrin 2,3:unc44
Homo sapiens ENSG00000115091   ARP3 actin-related protein 3 homolog (yeast)
Homo sapiens ENSG00000133627   ARP3 actin-related protein 3 homolog B (yeast)
Homo sapiens ENSG00000106526   ARP3 actin-related protein 3 homolog C (yeast)
Leishmania braziliensis LbrM.15.1360   actin-related protein 3, putative
Leishmania donovani LdBPK_151410.1   actin-related protein 3, putative arp3
Leishmania infantum LinJ.15.1410   actin-related protein 3, putative arp3
Leishmania major LmjF.15.1360   actin-related protein 3, putative arp3
Leishmania mexicana LmxM.15.1360   actin-related protein 3, putative arp3
Loa Loa (eye worm) LOAG_10525   Arp2/3 complex component protein 1
Mus musculus ENSMUSG00000026341   ARP3 actin-related protein 3
Mus musculus ENSMUSG00000056367   ARP3 actin-related protein 3B
Oryza sativa 4329867   Os02g0596900
Saccharomyces cerevisiae YJR065C   actin-related protein 3
Schistosoma japonicum Sjp_0202840   Actin-related protein 3, putative
Schistosoma japonicum Sjp_0016540   Ankyrin-2, putative
Schistosoma japonicum Sjp_0016520   Prolyl endopeptidase, putative
Schistosoma mansoni Smp_130310   prolyl oligopeptidase (S09 family)
Schmidtea mediterranea mk4.001493.05   Prolyl oligopeptidase
Trypanosoma brucei gambiense Tbg972.9.2830   actin related protein 3, putative
Trypanosoma brucei Tb927.9.5350   actin related protein 3, putative
Trypanosoma congolense TcIL3000_9_1800   actin-like protein 3, putative
Trypanosoma cruzi TcCLB.508277.260   actin-related protein 3, putative
Trypanosoma cruzi TcCLB.503913.20   actin-related protein 3, putative
Trichomonas vaginalis TVAG_371880   actin, putative

Essentiality

Bm1_17980 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.3850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.3850 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.3850 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.3850 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y71F9AL.16 Caenorhabditis elegans embryonic lethal wormbase
YJR065C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis beta-actin 375 aa 39.7% 358 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17980 (Brugia malayi), Arp2/3 complex component protein 1
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