Detailed view for Bm1_57310

Basic information

TDR Targets ID: 240318
Brugia malayi, Zinc finger, C2H2 type family protein
Source Database / ID:  GenBank

pI: 9.3276 | Length (AA): 178 | MW (Da): 20905 | Paralog Number: 52

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00096   Zinc finger, C2H2 type

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 69 2j7j (A) 2 72 32.00 0.0001 0.67 0.748887 -0.71
5 146 2gli (A) 105 254 26.00 0.0000026 0.72 0.906853 1.03
17 171 2i13 (A) 32 182 36.00 0 0.45 1.04489 1.11
30 59 1bhi (A) 5 32 46.00 0.078 0.47 0.658639 -0.63
145 177 1x6e (A) 9 41 24.00 0.04 0.17 0.448193 -0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130374)

Species Accession Gene Product
Brugia malayi Bm1_34395   hypothetical protein
Brugia malayi Bm1_55075   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_22970   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_53990   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_12455   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_11185   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_40925   hypothetical protein
Brugia malayi Bm1_21005   hypothetical protein
Brugia malayi Bm1_56135   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_12335   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_23150   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_29145   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_34390   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_09090   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_57105   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_19345   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_20070   hypothetical protein
Brugia malayi Bm1_20075   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_11775   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_04225   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_23160   hypothetical protein
Brugia malayi Bm1_25685   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_29165   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_35265   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_28990   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_26000   hypothetical protein
Brugia malayi Bm1_05760   hypothetical protein
Brugia malayi Bm1_04220   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_09095   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_57310   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_18365   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_25690   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_03715   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_17660   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_22965   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_13985   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_05155   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_47425   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_29160   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_01315   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_03710   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_04215   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_47430   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_25995   hypothetical protein
Brugia malayi Bm1_34385   hypothetical protein
Brugia malayi Bm1_17030   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_53995   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_11770   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_24640   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_22980   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_23155   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_04360   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_13485   Zinc finger, C2H2 type family protein
Loa Loa (eye worm) LOAG_15048   hypothetical protein
Loa Loa (eye worm) LOAG_15034   zinc finger protein
Loa Loa (eye worm) LOAG_13794   hypothetical protein
Loa Loa (eye worm) LOAG_12189   hypothetical protein
Loa Loa (eye worm) LOAG_11233   hypothetical protein
Loa Loa (eye worm) LOAG_12359   hypothetical protein
Loa Loa (eye worm) LOAG_13793   hypothetical protein
Loa Loa (eye worm) LOAG_11984   zinc finger protein
Loa Loa (eye worm) LOAG_12774   zinc finger protein
Loa Loa (eye worm) LOAG_13055   hypothetical protein
Loa Loa (eye worm) LOAG_14618   hypothetical protein
Loa Loa (eye worm) LOAG_13389   hypothetical protein
Loa Loa (eye worm) LOAG_13227   hypothetical protein
Loa Loa (eye worm) LOAG_10604   hypothetical protein
Loa Loa (eye worm) LOAG_14808   hypothetical protein
Loa Loa (eye worm) LOAG_11983   hypothetical protein
Loa Loa (eye worm) LOAG_14643   hypothetical protein
Loa Loa (eye worm) LOAG_12653   hypothetical protein
Loa Loa (eye worm) LOAG_13734   hypothetical protein
Loa Loa (eye worm) LOAG_12188   hypothetical protein
Loa Loa (eye worm) LOAG_16182   zinc finger protein
Loa Loa (eye worm) LOAG_14493   hypothetical protein
Loa Loa (eye worm) LOAG_15681   zinc finger protein
Loa Loa (eye worm) LOAG_15632   hypothetical protein
Loa Loa (eye worm) LOAG_14965   zinc finger protein
Loa Loa (eye worm) LOAG_12782   hypothetical protein
Loa Loa (eye worm) LOAG_15130   hypothetical protein
Loa Loa (eye worm) LOAG_00679   hypothetical protein
Loa Loa (eye worm) LOAG_14448   hypothetical protein
Loa Loa (eye worm) LOAG_12268   hypothetical protein
Loa Loa (eye worm) LOAG_15919   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57310 (Brugia malayi), Zinc finger, C2H2 type family protein
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