Detailed view for Bm1_15970

Basic information

TDR Targets ID: 240495
Brugia malayi, ras-related protein Rab-7
Source Database / ID:  GenBank

pI: 7.6045 | Length (AA): 212 | MW (Da): 23809 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0003924   GTPase activity  
GO:0005525   GTP binding  
GO:0005515   protein binding  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  
GO:0006913   nucleocytoplasmic transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Endocytosis (KEGG)
Phagosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 182 1ky2 (A) 4 180 67.00 0 1 1.70287 -1.46
9 181 5ldd (C) 5 178 76.00 0 1 1.79844 -1.8
11 196 1vg8 (A) 1007 1190 73.00 0.000000018 1 1.81406 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127616)

Species Accession Gene Product
Arabidopsis thaliana AT1G52280   RAB GTPase homolog G3D
Arabidopsis thaliana AT3G16100   RAB GTPase-like protein G3C
Arabidopsis thaliana AT4G09720   RAB GTPase homolog G3A
Arabidopsis thaliana AT3G18820   Ras-related protein RABG3f
Arabidopsis thaliana AT1G49300   RAB GTPase homolog G3E
Babesia bovis BBOV_III001720   Rab7
Brugia malayi Bm1_15970   ras-related protein Rab-7
Candida albicans CaO19.2245   similar to S. cerevisiae VPT7 (YML001W) rab family GTP-binding protein
Caenorhabditis elegans CELE_W03C9.3   Protein RAB-7
Cryptosporidium hominis Chro.70198   ras family GTPase
Cryptosporidium parvum cgd7_1680   Rab7 GTPase, putative
Dictyostelium discoideum DDB_G0269236   Rab GTPase
Drosophila melanogaster Dmel_CG5915   CG5915 gene product from transcript CG5915-RA
Echinococcus granulosus EgrG_000244200   ras protein Rab 7a
Entamoeba histolytica EHI_192810   small GTPase Rab7A
Entamoeba histolytica EHI_189990   Rab family GTPase
Echinococcus multilocularis EmuJ_000244200   ras protein Rab 7a
Homo sapiens ENSG00000075785   RAB7A, member RAS oncogene family
Leishmania braziliensis LbrM.18.0950   rab7 GTP binding protein, putative
Leishmania donovani LdBPK_180890.1   rab7 GTP binding protein, putative
Leishmania infantum LinJ.18.0890   rab7 GTP binding protein, putative
Leishmania major LmjF.18.0890   rab7 GTP binding protein, putative
Leishmania mexicana LmxM.18.0890   rab7 GTP binding protein, putative
Loa Loa (eye worm) LOAG_10263   RAB family member
Mus musculus ENSMUSG00000079477   RAB7, member RAS oncogene family
Neospora caninum NCLIV_065010   hypothetical protein
Oryza sativa 4325946   Os01g0714900
Oryza sativa 4339450   Os05g0536900
Oryza sativa 4327180   Os01g0227300
Oryza sativa 4339322   Os05g0516600
Plasmodium berghei PBANKA_0418200   ras-related protein RAB7, putative
Plasmodium falciparum PF3D7_0903200   ras-related protein RAB7
Plasmodium knowlesi PKNH_0700900   ras-related protein RAB7, putative
Plasmodium vivax PVX_098605   ras-related protein RAB7, putative
Plasmodium yoelii PY01824   putative Rab7 GTPase
Saccharomyces cerevisiae YML001W   Rab family GTPase YPT7
Schistosoma japonicum Sjp_0212570   ko:K07897 Ras-related protein Rab-7A, putative
Schistosoma mansoni Smp_067140   rab9 and
Schmidtea mediterranea mk4.001042.00   Ras-related protein Rab-7a
Schmidtea mediterranea mk4.000125.05   Putative rab9 and
Schmidtea mediterranea mk4.001757.02   Ras-related protein Rab-7a
Trypanosoma brucei gambiense Tbg972.9.6510   small GTPase, putative,GTP-binding protein, putative
Trypanosoma brucei Tb927.9.11000   ras-related protein RAB7, putative
Trypanosoma congolense TcIL3000_0_07150   small GTPase, putative
Trypanosoma cruzi TcCLB.508461.270   rab7 GTP binding protein, putative
Toxoplasma gondii TGME49_248880   GTPase RAB7
Theileria parva TP03_0666   small GTP-binding protein rab7, putative
Trichomonas vaginalis TVAG_079340   Rab7, putative
Trichomonas vaginalis TVAG_439150   Rab7, putative
Trichomonas vaginalis TVAG_159730   Rab78, putative

Essentiality

Bm1_15970 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2330 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2330 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2330 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.2330 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W03C9.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_W03C9.3 Caenorhabditis elegans larval arrest wormbase
PBANKA_0418200 Plasmodium berghei Essential plasmo
TGME49_248880 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_15970 (Brugia malayi), ras-related protein Rab-7
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