Detailed view for Bm1_45170

Basic information

TDR Targets ID: 240528
Brugia malayi, Leucine Rich Repeat family protein
Source Database / ID:  GenBank

pI: 7.515 | Length (AA): 853 | MW (Da): 98883 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12799   Leucine Rich repeats (2 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
64 211 2o6r (A) 29 181 12.00 0.25 0.31 0.250205 0
83 317 4psj (A) 23 263 30.00 0.0000008 1 0.563698 -0.29
96 156 2o6q (A) 24 86 23.00 0.24 1 0.307212 -0.5
97 423 3rgx (A) 60 411 28.00 0.0000053 1 0.504553 0.48
100 164 4k5u (B) 3 65 11.00 0.52 0.65 0.248902 -0.72
117 282 5gy2 (A) 280 446 28.00 0.00093 0.99 0.534807 -0.62
122 390 4u08 (A) 73 358 33.00 0.0000000032 1 0.603558 0.11
127 355 4qdh (A) 50 278 36.00 0.000000002 1 0.442664 0.55
127 344 4r6g (A) 106 346 33.00 0.0000000039 1 0.612769 -0.48
149 532 2id5 (A) 76 475 23.00 0.00005 1 0.533376 0.86
154 344 4r5d (A) 63 266 35.00 0.00000042 1 0.601116 -0.58
174 308 2z7x (B) 42 160 39.00 0.0081 0.33 0.109465 0.51
583 691 3s84 (A) 218 326 15.00 0 0.05 0.379484 -1.31
733 797 4z55 (A) 1167 1235 39.00 0.18 0.03 0.314402 1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_146385)

Species Accession Gene Product
Brugia malayi Bm1_45170   Leucine Rich Repeat family protein
Caenorhabditis elegans CELE_ZC262.3   Protein IGLR-2, isoform A
Drosophila melanogaster Dmel_CG16974   CG16974 gene product from transcript CG16974-RB
Loa Loa (eye worm) LOAG_00923   leucine Rich Repeat family protein
Schmidtea mediterranea mk4.000444.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_45170 (Brugia malayi), Leucine Rich Repeat family protein
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