Detailed view for Bm1_16895

Basic information

TDR Targets ID: 240555
Brugia malayi, LD47325p
Source Database / ID:  GenBank

pI: 5.6141 | Length (AA): 308 | MW (Da): 34771 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13620   Carboxypeptidase regulatory-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030246   carbohydrate binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132415)

Species Accession Gene Product
Arabidopsis thaliana AT3G62360   carbohydrate-binding-like fold-containing protein
Brugia malayi Bm1_28600   hypothetical protein
Brugia malayi Bm1_16895   LD47325p
Caenorhabditis elegans CELE_C02E11.1   Protein NRA-4, isoform A
Dictyostelium discoideum DDB_G0292032   hypothetical protein
Drosophila melanogaster Dmel_CG1371   CG1371 gene product from transcript CG1371-RA
Echinococcus granulosus EgrG_000057900   nodal modulator 1
Echinococcus multilocularis EmuJ_000057900   nodal modulator 1
Homo sapiens ENSG00000103512   NODAL modulator 1
Homo sapiens ENSG00000185164   NODAL modulator 2
Homo sapiens ENSG00000103226   NODAL modulator 3
Homo sapiens ENSG00000185164   nodal modulator 3-like
Loa Loa (eye worm) LOAG_05586   hypothetical protein
Mus musculus ENSMUSG00000030835   nodal modulator 1
Oryza sativa 4325779   Os01g0300600
Schistosoma japonicum Sjp_0310440   Nodal modulator 2 precursor, putative
Schistosoma japonicum Sjp_0084220   Nodal modulator 1 precursor, putative
Schistosoma japonicum Sjp_0084230   Nodal modulator 2 precursor, putative
Schistosoma japonicum Sjp_0084240   expressed protein
Schistosoma mansoni Smp_143730   carboxypeptidase regulatory region-containing
Schmidtea mediterranea mk4.001977.03  
Trichomonas vaginalis TVAG_491080   conserved hypothetical protein
Trichomonas vaginalis TVAG_133890   carboxypeptidase regulatory region-containing protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0027 0.285 0.454

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_16895 (Brugia malayi), LD47325p
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