Detailed view for Bm1_43195

Basic information

TDR Targets ID: 240609
Brugia malayi, ADP-specific Phosphofructokinase/Glucokinase conserved region family protein

Source Database / ID:  GenBank

pI: 8.7505 | Length (AA): 888 | MW (Da): 100315 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00698   Acyl transferase domain
PF04587   ADP-specific Phosphofructokinase/Glucokinase conserved region

Gene Ontology

Mouse over links to read term descriptions.
GO:0016773   phosphotransferase activity, alcohol group as acceptor  
GO:0016740   transferase activity  
GO:0008152   metabolic process  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 443 5ccf (A) 58 491 39.00 0 1 1.06857 -1.22
103 874 2vz8 (A) 71 773 14.00 0 1 0.792469 1.5
576 888 2c2n (A) 27 338 43.00 0 1 0.990577 -1.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_133202)

Species Accession Gene Product
Brugia malayi Bm1_43195   ADP-specific Phosphofructokinase/Glucokinase conserved region family protein
Caenorhabditis elegans CELE_C50D2.7   Protein C50D2.7
Dictyostelium discoideum DDB_G0287631   hypothetical protein
Drosophila melanogaster Dmel_CG6650   CG6650 gene product from transcript CG6650-RA
Echinococcus granulosus EgrG_000539900   ADP dependent glucokinase
Echinococcus multilocularis EmuJ_000539900   ADP dependent glucokinase
Homo sapiens ENSG00000159322   ADP-dependent glucokinase
Loa Loa (eye worm) LOAG_04105   hypothetical protein
Loa Loa (eye worm) LOAG_04106   hypothetical protein
Mus musculus ENSMUSG00000025236   ADP-dependent glucokinase
Schmidtea mediterranea mk4.001761.01  
Schmidtea mediterranea mk4.001761.03  


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_43195 (Brugia malayi), ADP-specific Phosphofructokinase/Glucokinase conserved region family protein
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