Detailed view for Bm1_46790

Basic information

TDR Targets ID: 240871
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 4.4296 | Length (AA): 786 | MW (Da): 88431 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04499   SIT4 phosphatase-associated protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 268 1xqr (A) 90 337 16.00 0 1 0.577372 -0.73
15 273 2x19 (B) 678 945 13.00 0 0.67 0.479917 -0.26
57 752 2qna (A) 128 841 10.00 0 0.71 0.939896 0.15
132 197 4iqn (A) 133 197 36.00 0.88 0.16 0.171969 1.17
622 786 4ke2 (A) 3 167 8.00 0.43 0 0.304524 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128556)

Species Accession Gene Product
Arabidopsis thaliana AT3G45190   SIT4 phosphatase-associated family protein
Arabidopsis thaliana AT2G28360   SIT4 phosphatase-associated family protein
Arabidopsis thaliana AT1G07990   SIT4 phosphatase-associated family protein
Arabidopsis thaliana AT1G30470   SIT4 phosphatase-associated family protein
Brugia malayi Bm1_46790   hypothetical protein
Candida albicans CaO19_5160   hypothetical protein
Candida albicans CaO19.12627   one of two genes similar to S. cerevisiae related proteins ( SAP4, SAP155, SAP185 and SAP190) that associate with SIT4 protein p
Candida albicans CaO19.5160   one of two genes similar to S. cerevisiae related proteins ( SAP4, SAP155, SAP185 and SAP190) that associate with SIT4 protein p
Dictyostelium discoideum DDB_G0268044   hypothetical protein
Drosophila melanogaster Dmel_CG10289   CG10289 gene product from transcript CG10289-RC
Echinococcus granulosus EgrG_000511300   serine:threonine protein phosphatase 6
Echinococcus granulosus EgrG_000165050   serine:threonine protein phosphatase 6
Echinococcus multilocularis EmuJ_000511300   serine:threonine protein phosphatase 6
Echinococcus multilocularis EmuJ_000165050   serine:threonine protein phosphatase 6
Homo sapiens ENSG00000100239   protein phosphatase 6, regulatory subunit 2
Homo sapiens ENSG00000105063   protein phosphatase 6, regulatory subunit 1
Homo sapiens ENSG00000110075   protein phosphatase 6, regulatory subunit 3
Loa Loa (eye worm) LOAG_01051   hypothetical protein
Mus musculus ENSMUSG00000052296   protein phosphatase 6, regulatory subunit 1
Mus musculus ENSMUSG00000036561   protein phosphatase 6, regulatory subunit 2
Mus musculus ENSMUSG00000024908   protein phosphatase 6, regulatory subunit 3
Oryza sativa 4339795   Os05g0592500
Oryza sativa 4337029   Os04g0620400
Saccharomyces cerevisiae YKR028W   Sap190p
Saccharomyces cerevisiae YJL098W   Sap185p
Schmidtea mediterranea mk4.001538.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_46790 (Brugia malayi), hypothetical protein
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