Detailed view for LmjF.23.0810
Basic information
Leishmania major, actin interacting protein-like protein
Source Database / ID: TriTrypDB GeneDB
pI: 6.7282 |
Length (AA): 519 |
MW (Da): 56924 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
GO:0016491 oxidoreductase activity
GO:0003824 catalytic activity
GO:0050660 FAD binding
GO:0055114 oxidation reduction
Metabolic Pathways
Structural information
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 20 | 518 | 1wvf (A) | 11 | 520 | 16.00 | 0 | 1 | 1.06 | -0.44 |
| 38 | 511 | 1wvf (A) | 25 | 512 | 18.00 | 0 | 1 | 1.14 | -0.37 |
| 20 | 519 | 1e8g (A) | 18 | 553 | 16.00 | 0 | 1 | 1.03439 | 0.36 |
| 21 | 513 | 3pm9 (A) | 11 | 475 | 34.00 | 0 | 1 | 1.3001 | -0.05 |
| 128 | 247 | 4ud8 (A) | 143 | 257 | 29.00 | 0.19 | 0.98 | 0.566014 | -0.15 |
| 156 | 243 | 2yvs (A) | 30 | 113 | 36.00 | 0.014 | 0.82 | 0.516357 | 0.47 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | amastigotes, metacyclic. | Fernandes MC |
-
Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.
Orthologs
Ortholog group members (OG5_128784)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT4G36400 | D-2-hydroxyglutarate dehydrogenase |
| Candida albicans | CaO19.300 | D-lactate dehydrogenase |
| Candida albicans | CaO19.7932 | D-lactate dehydrogenase |
| Caenorhabditis elegans | CELE_F54D5.12 | Protein F54D5.12 |
| Dictyostelium discoideum | DDB_G0270500 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG3835 | CG3835 gene product from transcript CG3835-RC |
| Homo sapiens | ENSG00000180902 | D-2-hydroxyglutarate dehydrogenase |
| Leishmania braziliensis | LbrM.23.0900 | actin interacting protein-like protein |
| Leishmania donovani | LdBPK_230980.1 | actin interacting protein-like protein |
| Leishmania infantum | LinJ.23.0980 | actin interacting protein-like protein |
| Leishmania major | LmjF.23.0810 | actin interacting protein-like protein |
| Leishmania mexicana | LmxM.23.0810 | actin interacting protein-like protein |
| Mycobacterium leprae | ML2631c | possible oxidoreductase |
| Mus musculus | ENSMUSG00000073609 | D-2-hydroxyglutarate dehydrogenase |
| Mus musculus | 666009 | predicted gene 7889 |
| Mycobacterium tuberculosis | Rv0161 | Possible oxidoreductase |
| Mycobacterium ulcerans | MUL_1038 | oxidoreductase |
| Oryza sativa | 4342598 | Os07g0187200 |
| Saccharomyces cerevisiae | YEL071W | Dld3p |
| Saccharomyces cerevisiae | YDL178W | Dld2p |
| Schmidtea mediterranea | mk4.038005.00 | D-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Schmidtea mediterranea | mk4.007793.01 | D-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Schmidtea mediterranea | mk4.015011.00 | |
| Schmidtea mediterranea | mk4.018804.00 | |
| Schmidtea mediterranea | mk4.007793.02 | D-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Schmidtea mediterranea | mk4.029572.00 | |
| Trypanosoma cruzi | TcCLB.504151.60 | actin interacting protein-like protein, putative |
| Trypanosoma cruzi | TcCLB.509461.10 | actin interacting protein-like protein, putative |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.3
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References