Detailed view for Bm1_57605

Basic information

TDR Targets ID: 240919
Brugia malayi, MGC80783 protein
Source Database / ID:  GenBank

pI: 8.4605 | Length (AA): 153 | MW (Da): 17007 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04756   OST3 / OST6 family, transporter family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 80 1v8k (A) 211 253 26.00 0.89 0.12 0.481746 0.65
69 126 3lxq (A) 274 322 45.00 0.19 0.16 0.368785 2.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131677)

Species Accession Gene Product
Arabidopsis thaliana AT4G29870   Oligosaccharyltransferase complex/magnesium transporter family protein
Arabidopsis thaliana AT2G19340   Oligosaccharyltransferase complex/magnesium transporter family protein
Brugia malayi Bm1_57605   MGC80783 protein
Dictyostelium discoideum DDB_G0279173   hypothetical protein
Drosophila melanogaster Dmel_CG9662   CG9662 gene product from transcript CG9662-RB
Echinococcus granulosus EgrG_000827200   oligosaccharyltransferase complex subunit
Entamoeba histolytica EHI_096150   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000827200   oligosaccharyltransferase complex subunit
Homo sapiens ENSG00000198856   oligosaccharyltransferase complex subunit (non-catalytic)
Loa Loa (eye worm) LOAG_03698   DC2 protein
Mus musculus ENSMUSG00000041084   oligosaccharyltransferase complex subunit
Oryza sativa 4329143   Os02g0315400
Schistosoma japonicum Sjp_0211670   similar to UPF0527 membrane protein, putative
Schistosoma mansoni Smp_181100   hypothetical protein
Schmidtea mediterranea mk4.002433.02   Oligosaccharyltransferase complex subunit OSTC

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57605 (Brugia malayi), MGC80783 protein
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