Detailed view for Bm1_48290

Basic information

TDR Targets ID: 241198
Brugia malayi, Homeobox domain containing protein
Source Database / ID:  GenBank

pI: 8.7218 | Length (AA): 212 | MW (Da): 24658 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00046   Homeobox domain
PF00412   LIM domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0043565   sequence-specific DNA binding  
GO:0008270   zinc ion binding  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 79 1v6g (A) 17 80 28.00 0.068 1 0.528355 1.05
120 184 1bw5 (A) 2 66 85.00 0 1 1.2942 -0.45
123 180 2h1k (A) 3 60 34.00 0.0014 0.55 0.844185 -1.83
133 170 2e19 (A) 15 52 37.00 0.64 0.48 0.620845 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131819)

Species Accession Gene Product
Brugia malayi Bm1_48290   Homeobox domain containing protein
Caenorhabditis elegans CELE_C04F1.3   Protein LIM-7
Drosophila melanogaster Dmel_CG10619   tailup
Echinococcus granulosus EgrG_001012000   Islet
Echinococcus multilocularis EmuJ_001012000   insulin gene enhancer protein ISL 2
Homo sapiens ENSG00000159556   ISL LIM homeobox 2
Homo sapiens ENSG00000016082   ISL LIM homeobox 1
Loa Loa (eye worm) LOAG_09498   homeobox domain-containing protein
Mus musculus ENSMUSG00000042258   ISL1 transcription factor, LIM/homeodomain
Mus musculus ENSMUSG00000032318   insulin related protein 2 (islet 2)
Schistosoma japonicum Sjp_0079680   ko:K09370 insulin gene enhancer protein ISL, putative
Schistosoma japonicum Sjp_0097550   hypothetical protein
Schistosoma mansoni Smp_142560   insulinprotein enhancer protein isl
Schmidtea mediterranea mk4.007857.00   Insulin gene enhancer protein isl-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_48290 (Brugia malayi), Homeobox domain containing protein
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