Detailed view for Bm1_48780

Basic information

TDR Targets ID: 241287
Brugia malayi, Partitioning defective-6 homolog alpha
Source Database / ID:  GenBank

pI: 7.6106 | Length (AA): 378 | MW (Da): 42372 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00564   PB1 domain
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 135 1wmh (B) 14 95 39.00 0.00000000012 1 0.834022 -1.6
169 293 2lc6 (A) 131 255 83.00 0 1 1.33089 -0.9
197 353 1u3b (A) 19 169 17.00 0 0.23 0.526544 -0.05
215 372 1fc6 (A) 160 315 16.00 0 0.23 0.575189 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131702)

Species Accession Gene Product
Brugia malayi Bm1_48780   Partitioning defective-6 homolog alpha
Caenorhabditis elegans CELE_T26E3.3   Protein PAR-6, isoform A
Drosophila melanogaster Dmel_CG5884   CG5884 gene product from transcript CG5884-RA
Echinococcus multilocularis EmuJ_001062700   partitioning defective protein 6
Homo sapiens ENSG00000124171   par-6 family cell polarity regulator beta
Homo sapiens ENSG00000178184   par-6 family cell polarity regulator gamma
Loa Loa (eye worm) LOAG_01497   PAR-6 protein
Mus musculus ENSMUSG00000044641   par-6 family cell polarity regulator beta
Mus musculus ENSMUSG00000056214   par-6 family cell polarity regulator gamma
Schistosoma japonicum Sjp_0060120   ko:K06093 partitioning defective protein 6, putative
Schistosoma mansoni Smp_048550   cell polarity protein
Schmidtea mediterranea mk4.000245.18   Synapse formation protein

Essentiality

Bm1_48780 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T26E3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26E3.3 Caenorhabditis elegans larval arrest wormbase
CELE_T26E3.3 Caenorhabditis elegans larval lethal wormbase
CELE_T26E3.3 Caenorhabditis elegans slow growth wormbase
CELE_T26E3.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_48780 (Brugia malayi), Partitioning defective-6 homolog alpha
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