pI: 6.1646 |
Length (AA): 471 |
MW (Da): 53882 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
102 | 471 | 2fug (4) | 35 | 409 | 43.00 | 0 | 1 | 1.25866 | 0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127839)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthMp043 | NADH dehydrogenase subunit 7 |
Arabidopsis thaliana | ArthCp080 | NADH dehydrogenase 49 kDa subunit |
Brugia malayi | Bm1_38090 | Probable NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrialprecursor |
Brugia malayi | Bm1_25145 | NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial |
Candida albicans | CaO19.6531 | potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUCM subunit and N. crassa and |
Candida albicans | CaO19.13884 | potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUCM subunit and N. crassa and |
Candida albicans | CaO19_6531 | hypothetical protein |
Caenorhabditis elegans | CELE_T26A5.3 | Protein NDUF-2.2 |
Caenorhabditis elegans | CELE_K09A9.5 | Protein GAS-1 |
Dictyostelium discoideum | DidioMp18 | NADH dehydrogenase subunit 7 |
Drosophila melanogaster | Dmel_CG1970 | CG1970 gene product from transcript CG1970-RB |
Drosophila melanogaster | Dmel_CG11913 | CG11913 gene product from transcript CG11913-RB |
Escherichia coli | b2286 | NADH:ubiquinone oxidoreductase, fused CD subunit |
Echinococcus granulosus | EgrG_000951700 | Golgi SNAP receptor complex |
Echinococcus granulosus | EgrG_000720300 | NADH dehydrogenase ubiquinone Fe S protein 2 |
Echinococcus multilocularis | EmuJ_000951700 | Golgi SNAP receptor complex |
Echinococcus multilocularis | EmuJ_000720300 | NADH dehydrogenase (ubiquinone) Fe S protein 2 |
Homo sapiens | ENSG00000158864 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) |
Loa Loa (eye worm) | LOAG_05466 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01369 | hypothetical protein |
Mus musculus | ENSMUSG00000013593 | NADH dehydrogenase (ubiquinone) Fe-S protein 2 |
Mycobacterium tuberculosis | Rv3148 | Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) |
Mycobacterium ulcerans | MUL_2462 | NADH dehydrogenase subunit D |
Oryza sativa | 6450198 | NADH dehydrogenase subunit 7 |
Oryza sativa | 3131489 | NADH dehydrogenase 49 kDa subunit |
Oryza sativa | 3131485 | ORF56 |
Schistosoma japonicum | Sjp_0205360 | ko:K08496 golgi SNAP receptor complex member 2 (Membrin), putative |
Schistosoma japonicum | Sjp_0205370 | ko:K03935 NADH dehydrogenase (ubiquinone) Fe-S protein 2, putative |
Schistosoma mansoni | Smp_127340 | NADH-ubiquinone oxidoreductase |
Schmidtea mediterranea | mk4.000370.01 | NADH dehydrogenase |
Schmidtea mediterranea | mk4.000370.00 | NADH dehydrogenase |
Schmidtea mediterranea | mk4.070622.02 | NADH dehydrogenase |
Wolbachia endosymbiont of Brugia malayi | Wbm0125 | NADH dehydrogenase subunit D |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K09A9.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K09A9.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_T26A5.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T26A5.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T26A5.3 | Caenorhabditis elegans | sterile | wormbase |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | Compounds | References |