pI: 7.1885 |
Length (AA): 217 |
MW (Da): 23380 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
16 | 184 | 1r2q (A) | 16 | 184 | 91.00 | 0.000000083 | 1 | 1.9335 | -1.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126724)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G54840 | Rab-like GTP-ase |
Arabidopsis thaliana | AT5G45130 | Ras-related protein RABF2a |
Arabidopsis thaliana | AT4G19640 | Rab5 GTPase-like protein Ara7 |
Babesia bovis | BBOV_IV002910 | Ras-related protein Rab-5 |
Brugia malayi | Bm1_36215 | Ras-related protein Rab-5B |
Candida albicans | CaO19.6364 | similar to S. cerevisiae VPS21 (YOR089C) Rab5-like GTPase involved in vacuolar protein sorting |
Candida albicans | CaO19.7216 | one of two genes similar to S. cerevisiae VPT52 (YKR014C) rab5-like GTPase involved in vacuolar protein sorting and endocytosis |
Candida albicans | CaO19.13721 | similar to S. cerevisiae VPS21 (YOR089C) Rab5-like GTPase involved in vacuolar protein sorting |
Candida albicans | CaO19.8221 | similar to S. cerevisiae VPS21 (YOR089C) Rab5-like GTPase involved in vacuolar protein sorting |
Candida albicans | CaO19.589 | similar to S. cerevisiae VPS21 (YOR089C) Rab5-like GTPase involved in vacuolar protein sorting |
Caenorhabditis elegans | CELE_F26H9.6 | Protein RAB-5 |
Cryptosporidium hominis | Chro.30357 | Rab5 |
Cryptosporidium parvum | cgd3_3150 | Rab5 like small GTpase |
Dictyostelium discoideum | DDB_G0271984 | Rab GTPase |
Drosophila melanogaster | Dmel_CG3664 | CG3664 gene product from transcript CG3664-RC |
Echinococcus granulosus | EgrG_000990600 | ras protein rab |
Entamoeba histolytica | EHI_026420 | Rab family GTPase |
Entamoeba histolytica | EHI_117960 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_000990600 | ras protein rab |
Homo sapiens | ENSG00000111540 | RAB5B, member RAS oncogene family |
Homo sapiens | ENSG00000108774 | RAB5C, member RAS oncogene family |
Homo sapiens | ENSG00000124209 | RAB22A, member RAS oncogene family |
Homo sapiens | ENSG00000144566 | RAB5A, member RAS oncogene family |
Leishmania braziliensis | LbrM.29.2670 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.18.1230 | ras-related protein rab-5, putative |
Leishmania donovani | LdBPK_130220.1 | ras-related protein RAB5B, putative |
Leishmania donovani | LdBPK_181140.1 | Ras-related protein Rab5A, putative |
Leishmania infantum | LinJ.13.0220 | small Rab GTP binding protein, putative |
Leishmania infantum | LinJ.18.1140 | ras-related protein rab-5, putative |
Leishmania major | LmjF.13.0220 | small Rab GTP binding protein, putative |
Leishmania major | LmjF.18.1130 | ras-related protein rab-5, putative |
Leishmania mexicana | LmxM.18.1130 | ras-related protein rab-5, putative |
Leishmania mexicana | LmxM.13.0220 | small Rab GTP binding protein, putative |
Loa Loa (eye worm) | LOAG_01129 | Rab5 |
Mus musculus | ENSMUSG00000019173 | RAB5C, member RAS oncogene family |
Mus musculus | ENSMUSG00000000711 | RAB5B, member RAS oncogene family |
Mus musculus | 19334 | RAB22A, member RAS oncogene family |
Mus musculus | ENSMUSG00000017831 | RAB5A, member RAS oncogene family |
Neospora caninum | NCLIV_038540 | RAB22A, member RAS oncogene family, related |
Oryza sativa | 4352862 | Os12g0631100 |
Oryza sativa | 4331646 | Os03g0151900 |
Oryza sativa | 4341888 | Os06g0687100 |
Oryza sativa | 4333662 | Os03g0666500 |
Oryza sativa | 4348725 | Os10g0441800 |
Plasmodium berghei | PBANKA_0206500 | ras-related protein Rab-5C, putative |
Plasmodium falciparum | PF3D7_0106800 | ras-related protein Rab-5C |
Plasmodium knowlesi | PKNH_0206700 | ras-related protein Rab-5C, putative |
Plasmodium vivax | PVX_081430 | ras-related protein Rab-5C, putative |
Plasmodium yoelii | PY01029 | Rab5c GTPase-related |
Saccharomyces cerevisiae | YOR089C | Rab family GTPase VPS21 |
Saccharomyces cerevisiae | YKR014C | Rab family GTPase YPT52 |
Schistosoma japonicum | Sjp_0035820 | ko:K07888 Ras-related protein Rab-5B, putative |
Schistosoma mansoni | Smp_040570.1 | rab5 |
Schistosoma mansoni | Smp_040570.2 | rab5 |
Schmidtea mediterranea | mk4.001933.02 | Drab5 |
Schmidtea mediterranea | mk4.001858.07 | Ras-related protein Rab-30 |
Schmidtea mediterranea | mk4.008787.00 | Ras-related protein Rab-17 |
Schmidtea mediterranea | mk4.095075.00 | |
Trypanosoma brucei gambiense | Tbg972.11.5230 | small GTPase, putative,small GTP-binding protein Rab5b, putative |
Trypanosoma brucei gambiense | Tbg972.10.15640 | ras-related protein rab-5,GTP binding protein, putative |
Trypanosoma brucei | Tb927.10.12960 | Ras-related protein Rab5A |
Trypanosoma brucei | Tb927.11.4570 | Ras-related protein Rab5B |
Trypanosoma congolense | TcIL3000.11.4670 | ras-related protein RAB5B, putative |
Trypanosoma congolense | TcIL3000_10_11060 | Ras-related protein Rab5A, putative |
Trypanosoma cruzi | TcCLB.509805.60 | Ras-related protein Rab5A, putative |
Trypanosoma cruzi | TcCLB.511269.4 | Ras-related protein Rab5A, putative |
Trypanosoma cruzi | TcCLB.506227.180 | ras-related protein RAB5B, putative |
Toxoplasma gondii | TGME49_267810 | Rab 5 |
Theileria parva | TP01_0639 | GTP-binding protein rab5, putative |
Trichomonas vaginalis | TVAG_424920 | RAB 3 and, putative |
Trichomonas vaginalis | TVAG_470600 | GTP-binding protein ypt10, putative |
Trichomonas vaginalis | TVAG_060820 | RAB, putative |
Trichomonas vaginalis | TVAG_300910 | Rabx18 protein, putative |
Trichomonas vaginalis | TVAG_044270 | RAB, putative |
Trichomonas vaginalis | TVAG_498380 | Rab20, putative |
Trichomonas vaginalis | TVAG_052730 | Rabx20 protein, putative |
Trichomonas vaginalis | TVAG_388290 | RAB, putative |
Trichomonas vaginalis | TVAG_368730 | Rab12, putative |
Trichomonas vaginalis | TVAG_081590 | Rab5b, putative |
Trichomonas vaginalis | TVAG_423520 | RAB, putative |
Trichomonas vaginalis | TVAG_008100 | Rabx38 protein, putative |
Trichomonas vaginalis | TVAG_340860 | Rab7g protein, putative |
Trichomonas vaginalis | TVAG_489360 | Rab7g protein, putative |
Trichomonas vaginalis | TVAG_000080 | RAB 3 and, putative |
Trichomonas vaginalis | TVAG_038190 | small GTPase rabi, putative |
Trichomonas vaginalis | TVAG_106390 | RAB-36 and, putative |
Trichomonas vaginalis | TVAG_320300 | GTP-binding protein Rab2, putative |
Trichomonas vaginalis | TVAG_119750 | Rab17, putative |
Trichomonas vaginalis | TVAG_222450 | Rabx18 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.12960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12960 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.12960 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.2160 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2160 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2160 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.02.2160 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F26H9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F26H9.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F26H9.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F26H9.6 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0206500 | Plasmodium berghei | Dispensable | plasmo |
TGME49_267810 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.