Detailed view for Bm1_47975

Basic information

TDR Targets ID: 242054
Brugia malayi, Tetraspanin family protein
Source Database / ID:  GenBank

pI: 8.0311 | Length (AA): 243 | MW (Da): 26575 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00335   Tetraspanin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 47 5bud (A) 188 224 42.00 0.58 0.05 0.403548 1.44
117 202 3x0g (A) 112 198 15.00 0 0.31 0.436709 -0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131579)

Species Accession Gene Product
Brugia malayi Bm1_47975   Tetraspanin family protein
Caenorhabditis elegans CELE_T23D8.2   Protein TSP-7
Drosophila melanogaster Dmel_CG8666   Tetraspanin 39D
Drosophila melanogaster Dmel_CG9494   Tetraspanin 29Fa
Echinococcus granulosus EgrG_001070300   TSP2
Echinococcus granulosus EgrG_001021500   TSP4
Echinococcus granulosus EgrG_001077400   tetraspanin
Echinococcus granulosus EgrG_001014500   tetraspanin
Echinococcus granulosus EgrG_000977700   cd63 antigen
Echinococcus granulosus EgrG_000328400   tetraspanin
Echinococcus granulosus EgrG_001077100   TSP5
Echinococcus multilocularis EmuJ_001077400   tetraspanin
Echinococcus multilocularis EmuJ_000977700   cd63 antigen
Echinococcus multilocularis EmuJ_001014500   tetraspanin
Echinococcus multilocularis EmuJ_001077100   TSP5
Echinococcus multilocularis EmuJ_000289200   Tetraspanin-5
Echinococcus multilocularis EmuJ_001070300   TSP2
Echinococcus multilocularis EmuJ_001077300   tetraspanin
Echinococcus multilocularis EmuJ_000328400   Tetraspanin-5
Echinococcus multilocularis EmuJ_000355400   tetraspanin
Echinococcus multilocularis EmuJ_001077500   tetraspanin
Echinococcus multilocularis EmuJ_001077200   tetraspanin
Homo sapiens ENSG00000135404   CD63 molecule
Loa Loa (eye worm) LOAG_07930   hypothetical protein
Mus musculus ENSMUSG00000025351   CD63 antigen
Schistosoma japonicum Sjp_0018800   IPR000301,CD9/CD37/CD63 antigen;IPR008952,Tetraspanin,domain-containing
Schistosoma mansoni Smp_176870   cd63 antigen-like
Schistosoma mansoni Smp_142230   cd63 antigen-like
Schistosoma mansoni Smp_173150   cd63 antigen-like
Schmidtea mediterranea mk4.006386.03  
Schmidtea mediterranea mk4.007777.01  
Schmidtea mediterranea mk4.002847.02  
Schmidtea mediterranea mk4.001921.00  
Schmidtea mediterranea mk4.002492.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CD63 molecule Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_47975 (Brugia malayi), Tetraspanin family protein
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