Detailed view for Bm1_00615

Basic information

TDR Targets ID: 242563
Brugia malayi, adenylate cyclase, type IX
Source Database / ID:  GenBank

pI: 6.4974 | Length (AA): 794 | MW (Da): 89206 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016849   phosphorus-oxygen lyase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
121 290 1azs (A) 378 547 55.00 0 1 0.962006 -1.07
398 481 4ryo (A) 40 117 40.00 0.067 0.1 0.253893 1.57
580 781 4p2f (A) 238 425 35.00 0 1 0.677308 -0.52
586 777 1azs (B) 879 1075 48.00 0 1 0.845714 -0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132277)

Species Accession Gene Product
Brugia malayi Bm1_00615   adenylate cyclase, type IX
Caenorhabditis elegans CELE_F17C8.1   Protein ACY-1
Dictyostelium discoideum DDB_G0281545   adenylate cyclase
Drosophila melanogaster Dmel_CG9210   Adenylyl cyclase 35C
Echinococcus granulosus EgrG_001004700   adenylate cyclase 9
Echinococcus granulosus EgrG_000840050   adenylate cyclase type IX
Echinococcus multilocularis EmuJ_001002400   adenylate cyclase 9
Echinococcus multilocularis EmuJ_001004700   adenylate cyclase 9
Echinococcus multilocularis EmuJ_000840050   adenylate cyclase type IX
Homo sapiens ENSG00000162104   adenylate cyclase 9
Loa Loa (eye worm) LOAG_04500   hypothetical protein
Loa Loa (eye worm) LOAG_11276   hypothetical protein
Mus musculus ENSMUSG00000005580   adenylate cyclase 9
Schistosoma japonicum Sjp_0078110   ko:K08049 adenylate cyclase 9, putative
Schistosoma mansoni Smp_102340.2   adenylate cyclase
Schistosoma mansoni Smp_102340.1   adenylate cyclase
Schmidtea mediterranea mk4.000068.16   Adenylate cyclase type IX, putative
Schmidtea mediterranea mk4.008281.01   Adenylate cyclase type 3
Schmidtea mediterranea mk4.014882.00  
Schmidtea mediterranea mk4.015955.01   Adenylate cyclase type IX, putative
Schmidtea mediterranea mk4.003635.03   Adenylate cyclase type IX, putative
Schmidtea mediterranea mk4.014882.01   Adenylate cyclase type 3
Schmidtea mediterranea mk4.001638.00   Adenylate cyclase type 3
Schmidtea mediterranea mk4.006119.00   Adenylate cyclase type 3
Schmidtea mediterranea mk4.058965.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adenylate cyclase 9 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Adenylate Cyclase (4.6.1.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00615 (Brugia malayi), adenylate cyclase, type IX
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