Detailed view for Bm1_32855

Basic information

TDR Targets ID: 242569
Brugia malayi, FtsJ-like methyltransferase family protein
Source Database / ID:  GenBank

pI: 5.4735 | Length (AA): 532 | MW (Da): 61313 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01728   FtsJ-like methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0003676   nucleic acid binding  
GO:0032259   methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 518 2bpt (A) 296 813 10.00 0 0.18 1.01702 0.22
84 273 2plw (A) 2 199 21.00 0.000000023 0.96 0.624743 -0.44
94 270 2plw (A) 2 196 21.00 0 0.91 0.516807 -0.13
132 177 1uey (A) 18 62 42.00 0.16 0.08 0.355266 1.3
177 278 2px2 (A) 138 234 15.00 0 0.2 0.336829 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131351)

Species Accession Gene Product
Babesia bovis BBOV_I003250   ribosomal RNA large subunit methyltransferase J domain containing protein
Brugia malayi Bm1_32855   FtsJ-like methyltransferase family protein
Caenorhabditis elegans CELE_Y40D12A.1   Protein Y40D12A.1, isoform B
Cryptosporidium hominis Chro.70293   hypothetical protein
Cryptosporidium parvum cgd7_2570   adrift-like. FTSJ family RNA methylase
Drosophila melanogaster Dmel_CG5032   adrift
Homo sapiens ENSG00000180917   cap methyltransferase 2
Loa Loa (eye worm) LOAG_09900   hypothetical protein
Mus musculus ENSMUSG00000046441   cap methyltransferase 2
Neospora caninum NCLIV_067500   ftsJ-like methyltransferase domain-containing protein, putative
Plasmodium yoelii PY04767   hypothetical protein
Toxoplasma gondii TGME49_278500   ribosomal RNA large subunit methyltransferase J protein
Theileria parva TP03_0172   hypothetical protein, conserved

Essentiality

Bm1_32855 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_278500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_32855 (Brugia malayi), FtsJ-like methyltransferase family protein
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