Detailed view for Bm1_02785

Basic information

TDR Targets ID: 242822
Brugia malayi, WLPL439
Source Database / ID:  GenBank

pI: 9.0497 | Length (AA): 325 | MW (Da): 37125 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Retinol metabolism (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131173)

Species Accession Gene Product
Arabidopsis thaliana AT1G06820   carotenoid isomerase
Brugia malayi Bm1_02785   WLPL439
Brugia malayi Bm1_11455   all-trans-13,14-dihydroretinol saturase
Homo sapiens ENSG00000042445   retinol saturase (all-trans-retinol 13,14-reductase)
Loa Loa (eye worm) LOAG_09468   hypothetical protein
Mus musculus ENSMUSG00000056666   retinol saturase (all trans retinol 13,14 reductase)
Mycobacterium ulcerans MUL_1423   dehydrogenase
Oryza sativa 4350758   Os11g0572700

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_02785 (Brugia malayi), WLPL439
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