Detailed view for Bm1_06430

Basic information

TDR Targets ID: 242972
Brugia malayi, TBC domain containing protein
Source Database / ID:  GenBank

pI: 5.7651 | Length (AA): 1012 | MW (Da): 115405 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00566   Rab-GTPase-TBC domain
PF00640   Phosphotyrosine interaction domain (PTB/PID)
PF12473   Kinesin protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0043547   positive regulation of GTPase activity  
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0005097   Rab GTPase activator activity  
GO:0005096   GTPase activator activity  
GO:0032313   regulation of Rab GTPase activity  
GO:0007049   cell cycle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 183 3so6 (A) 43 172 22.00 0.00000000014 1 0.431464 -1.06
47 192 2ela (B) 499 644 11.00 0.0000075 0.13 0.212369 -0.46
429 724 4p17 (A) 15 302 24.00 0 1 0.49829 -0.64
460 748 4nc6 (A) 541 828 60.00 0 1 1.17587 -1.99
479 745 3hzj (B) 531 797 64.00 0 1 1.11213 -1.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131420)

Species Accession Gene Product
Brugia malayi Bm1_06430   TBC domain containing protein
Caenorhabditis elegans CELE_F35H12.2   Protein TBC-11, isoform C
Drosophila melanogaster Dmel_CG7112   GTPase activating protein and centrosome-associated ortholog (H. sapiens)
Echinococcus granulosus EgrG_000150400   rab GTPase activating protein 1
Echinococcus multilocularis EmuJ_000150400   rab GTPase activating protein 1
Homo sapiens ENSG00000011454   RAB GTPase activating protein 1
Loa Loa (eye worm) LOAG_04027   TBC domain-containing protein
Loa Loa (eye worm) LOAG_01972   hypothetical protein
Mus musculus ENSMUSG00000035437   RAB GTPase activating protein 1
Mus musculus ENSMUSG00000026721   RAB GTPase activating protein 1-like
Onchocerca volvulus OVOC3305  
Schistosoma japonicum Sjp_0047320   Rab GTPase-activating protein 1, putative
Schistosoma japonicum Sjp_0133850   Rab GTPase-activating protein 1, putative
Schistosoma japonicum Sjp_0309190   Rab GTPase-activating protein 1, putative
Schistosoma mansoni Smp_007210   rab6 gtpase activating protein gapcena (rabgap1 protein)
Schmidtea mediterranea mk4.000456.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_06430 (Brugia malayi), TBC domain containing protein
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