Detailed view for Bm1_22280

Basic information

TDR Targets ID: 243233
Brugia malayi, Variant SH3 domain containing protein
Source Database / ID:  GenBank

pI: 8.4317 | Length (AA): 591 | MW (Da): 68394 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 176 4uos (A) 1 137 14.00 0.23 0.01 0.303958 -0.48
72 172 4k2u (A) 57 168 33.00 0.68 0.13 0.260897 0.17
130 591 2de0 (X) 108 568 43.00 0 1 1.22503 -0.2
233 518 2hhc (A) 14 316 18.00 0 0.93 0.504126 0.42
517 578 2e5k (A) 249 311 29.00 0 0.16 0.176107 0.54
529 583 2bz8 (A) 3 55 30.00 0 0.29 0.380263 -0.57
531 578 2jt4 (A) 10 58 25.00 0 0.18 0.310418 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132113)

Species Accession Gene Product
Brugia malayi Bm1_22280   Variant SH3 domain containing protein
Caenorhabditis elegans CELE_C10F3.6   Protein FUT-8
Drosophila melanogaster Dmel_CG2448   alpha1,6-fucosyltransferase
Echinococcus granulosus EgrG_000826900   alpha 16 fucosyltransferase
Echinococcus multilocularis EmuJ_000826900   alpha (1,6) fucosyltransferase
Homo sapiens ENSG00000033170   fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
Loa Loa (eye worm) LOAG_06726   variant SH3 domain-containing protein
Mus musculus ENSMUSG00000021065   fucosyltransferase 8
Schistosoma japonicum Sjp_0094930   Alpha-(1,6)-fucosyltransferase, putative
Schistosoma japonicum Sjp_0213240   ko:K00717 glycoprotein 6-alpha-L-fucosyltransferase [EC2.4.1.68], putative
Schistosoma mansoni Smp_175120.2   hypothetical protein
Schistosoma mansoni Smp_175120.1   hypothetical protein
Schmidtea mediterranea mk4.008212.01   Alpha-(1,6)-fucosyltransferase
Schmidtea mediterranea mk4.000060.13  
Schmidtea mediterranea mk4.008391.00  
Schmidtea mediterranea mk4.000060.15   Alpha-(1,6)-fucosyltransferase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fucosyltransferase 8 (alpha (1,6) fucosyltransferase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_22280 (Brugia malayi), Variant SH3 domain containing protein
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