Detailed view for Bm1_35535

Basic information

TDR Targets ID: 243392
Brugia malayi, DOMON domain containing protein
Source Database / ID:  GenBank

pI: 6.1154 | Length (AA): 639 | MW (Da): 73222 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03351   DOMON domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004500   dopamine beta-monooxygenase activity  
GO:0006548   histidine catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
153 235 5k6d (A) 2 73 35.00 0.99 0.45 0.36389 -0.25
157 222 2m74 (A) 122 178 35.00 0.0034 1 0.375286 0.22
181 222 1whe (A) 43 82 46.00 0.42 0.95 0.339728 0.95
184 224 1jl9 (A) 7 45 31.00 0 0.8 0.358863 0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134925)

Species Accession Gene Product
Brugia malayi Bm1_00575   DOMON domain containing protein
Brugia malayi Bm1_35535   DOMON domain containing protein
Caenorhabditis elegans CELE_C34C6.3   Protein C34C6.3
Caenorhabditis elegans CELE_C09F9.2   Protein C09F9.2
Drosophila melanogaster Dmel_CG12781   CG12781 gene product from transcript CG12781-RC
Loa Loa (eye worm) LOAG_12730   hypothetical protein
Loa Loa (eye worm) LOAG_13130   hypothetical protein
Loa Loa (eye worm) LOAG_11288   DOMON domain-containing protein
Loa Loa (eye worm) LOAG_15424   hypothetical protein
Loa Loa (eye worm) LOAG_06867   DOMON domain-containing protein
Loa Loa (eye worm) LOAG_12963   hypothetical protein
Onchocerca volvulus OVOC11601  
Onchocerca volvulus OVOC11596  
Onchocerca volvulus OVOC10057  
Plasmodium berghei PBANKA_0517000   early transcribed membrane protein
Plasmodium yoelii PY07506   Drosophila melanogaster CG12781 gene product

Essentiality

Bm1_35535 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0517000 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_35535 (Brugia malayi), DOMON domain containing protein
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