Detailed view for Bm1_17810

Basic information

TDR Targets ID: 243396
Brugia malayi, vacuolar ATP synthase subunit H
Source Database / ID:  GenBank

pI: 8.787 | Length (AA): 86 | MW (Da): 9618 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05493   ATP synthase subunit H

Gene Ontology

Mouse over links to read term descriptions.
GO:0033179   proton-transporting V-type ATPase, V0 domain  
GO:0015078   hydrogen ion transmembrane transporter activity  
GO:0015991   ATP hydrolysis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)
Phagosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129204)

Species Accession Gene Product
Arabidopsis thaliana AT5G55290   ATPase, V0 complex, subunit E
Arabidopsis thaliana AT4G26710   ATPase, V0 complex, subunit E
Brugia malayi Bm1_17810   vacuolar ATP synthase subunit H
Caenorhabditis elegans CELE_F49C12.13   Protein VHA-17
Drosophila melanogaster Dmel_CG1268   Vacuolar H[+] ATPase M9.7 subunit a
Drosophila melanogaster Dmel_CG7625   Vacuolar H[+] ATPase M9.7 subunit b
Drosophila melanogaster Dmel_CG11589   Vacuolar H[+] ATPase M9.7 subunit c
Echinococcus granulosus EgrG_001158700   V type proton ATPase subunit e 1
Echinococcus granulosus EgrG_000936100   ATPase V0 complex subunit E
Echinococcus multilocularis EmuJ_001158700   V type proton ATPase subunit e 1
Echinococcus multilocularis EmuJ_000936100   ATPase, V0 complex, subunit E
Homo sapiens 8992   ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Homo sapiens ENSG00000171130   ATPase, H+ transporting V0 subunit e2
Leishmania braziliensis LbrM.28.0660   hypothetical protein, conserved
Leishmania donovani LdBPK_280680.1   ATP synthase subunit H, putative
Leishmania infantum LinJ.28.0680   hypothetical protein, conserved
Leishmania major LmjF.28.0640   hypothetical protein, conserved
Leishmania mexicana LmxM.28.0640   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_13419   vacuolar ATP synthase subunit H
Mus musculus ENSMUSG00000039347   ATPase, H+ transporting, lysosomal V0 subunit E2
Mus musculus ENSMUSG00000015575   ATPase, H+ transporting, lysosomal V0 subunit E
Neospora caninum NCLIV_066570   hypothetical protein, conserved
Oryza sativa 4337284   Os04g0660600
Plasmodium berghei PBANKA_0619400   V-type ATPase V0 subunit e, putative
Plasmodium falciparum PF3D7_0721900   V-type ATPase V0 subunit e, putative
Plasmodium knowlesi PKNH_0317300   V-type ATPase V0 subunit e, putative
Plasmodium vivax PVX_096253   conserved Plasmodium protein, unknown function
Saccharomyces cerevisiae YCL005W-A   H(+)-transporting V0 sector ATPase subunit E
Schistosoma japonicum Sjp_0008990   ko:K02153 V-type H+-transporting ATPase subunit H, putative
Schmidtea mediterranea mk4.006125.01  
Trypanosoma brucei Tb927.11.8130   ATP synthase subunit H, putative
Trypanosoma cruzi TcCLB.508815.150   ATP synthase subunit H, putative
Trichomonas vaginalis TVAG_087150   conserved hypothetical protein

Essentiality

Bm1_17810 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0415 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0415 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0415 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.0415 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F49C12.13 Caenorhabditis elegans embryonic lethal wormbase
CELE_F49C12.13 Caenorhabditis elegans larval arrest wormbase
CELE_F49C12.13 Caenorhabditis elegans larval lethal wormbase
CELE_F49C12.13 Caenorhabditis elegans slow growth wormbase
CELE_F49C12.13 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17810 (Brugia malayi), vacuolar ATP synthase subunit H
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